Studies on Diazepines. XXII. Synthesis of Monocyclic 1,4-Dihetero Seven-Membered Ring Compounds Using Thermal Valence Bond Isomerization of Tricyclo [4.1.0.0^<2.5>] heptane Systems

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概要

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• The 3-azatricyclo [4.1.0.0^<2.5>] heptanes (11-14) prepared readily from pyridines via 2-azabicyclo [2.2.0] hexa-5-enes (10) were found to be useful synthons for seven-membered heterocycles. The thermolysis of the compounds (11-13) having an oxygen, a nitrogen, or a sulfur atom in the 7-position resulted in valence bond isomerization with ring opening, giving rise to the corresponding 1,4-dihetero seven-membered ring compounds, 1,4-oxazepine (15), 1,4-diazepine (16), and 1,4-thiazepine (17) derivatives. The 3-azatricycloheptane (14) having no hetero atom in the 7-position also afforded the azepine derivative (18).

• 公益社団法人日本薬学会の論文
• 1985-10-25

著者

• 土屋 隆

  School of Pharmacy, Hokuriku University

• 栗田 城治

  School of Pharmacy, Hokuriku University

• 栗田 城治

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 酒井 弘一

  School of Pharmacy, Hokuriku University

• 栗田 城治

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 岩田 邦義

  School of Pharmacy, Hokuriku University

• 岩田 邦義

  北陸大学 薬

• 酒井 弘一

  School Of Pharmacy Hokuriku University

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