Studies of Seven-Membered Heterocycles. XXXII. : Synthesis of N-Unsubstituted 1H-1,4-Benzodiazepines Stabilized by Intramolecular Hydrogen Bonding

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概要

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• The stable N-unsubstituted 1H-1,4-benzodiazepines (12a-l) having a carbonyl group or its analogue at the 2- or 9-position were prepared from the 4-azidoquinolines (13a-l) by photoreaction in the presence of sodium methoxide.It is known that N-unsubstituetd 1H-1,4-benzodiazepines having no carbonyl group are too unstable to be isolated.Based on the spectral data, the benzodiazepines (12) isolated are assumed to be stabilized by intramolecular hydrogen bonding between the 1-NH hydrogen and the 2- or 9-carbonyl oxygen, thus allowing their isolation.

• 公益社団法人日本薬学会の論文
• 1990-11-25

著者

• 土屋 隆

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 指田 春喜

  北陸大学薬学部

• 指田 春喜

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 土屋 隆

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 要 衛

  Faculty of Pharmaceutical Sciences, Hokuriku University

• 要 衛

  北陸大学薬学部

• 要 衛

  Faculty Of Pharmaceutical Sciences Of Hokuriku University

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