Stereospecific Synthesis of (R)- and (S)-Baclofen and (R)- and (S)-PCPGABA [4-Amino-2-(4-chlorophenyl)butyric Acid]via (R)- and (S)-3-(4-Chlorophenyl)pyrrolidines
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概要
- 論文の詳細を見る
(R)- and (S)-Baclofen and (R)- and (S)-PCPGABA [4-amino-2-(4-chlorophenyl)butyric acid] were stereospecifically synthesized via (R)- and (S)-3-(4-chlorophenyl)pyrrolidines, starting from trans-4-hydroxy-L-proline. The syntheses involve two key operations, namely, 1) a stereoselective hydrogenation of dehydroproline derivatives controlled by the C-2 carboxyl function and 2) an effective ruthenium tetroxide oxidation to prepare chiral 3- and 4-(4-chlorophenyl)pyrrolidin-2-ones, which are dehydrated precursors of the target molecules.
- 公益社団法人日本薬学会の論文
- 1995-08-15
著者
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吉藤 茂行
Faculty of Pharmaceutical Sciences, Hokuriku University
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吉藤 茂行
Faculty Of Pharmaceutical Sciences Of Hokuriku University
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要 衛
Faculty of Pharmaceutical Sciences, Hokuriku University
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要 衛
Faculty Of Pharmaceutical Sciences Of Hokuriku University
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Yoshifuji Shigeyuki
Faculty Of Pharmaceutical Sciences Of Hokuriku University
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Kaname Mamoru
Faculty Of Pharmaceutical Sciences Hokuriku University
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吉藤 茂行
Faculty Of Pharmaceutical Sciences Hokuriku University
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