Ruthenium Tetroxide Oxidation of N-Acylated Alkylamines: A New General Syuthesis of Imides(Organic,Chemical)
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概要
- 論文の詳細を見る
Oxidation of various N-acylalkylamines with ruthenium tetroxide (RuO_4) was systematically investigated. N-Acylalkylamines having an electron-donating group at the α- or β-position with respect to amide nitrogen or an electron-donating alkyl function in the acyl group were smoothly oxidized to the corresponding imides in excellent yields. On the other hand, N-acylalkylamines having an electron-withdrawing group were not oxidized at all, and most of the starting material was recovered. It appears that the reactivity of N-acylalkylamines is closely correlated with the acidity of the carboxylic acid from which the N-acyl group is derived, and also with the electron density at the methylene moiety adjacent to the amide nitrogen atom.
- 社団法人日本薬学会の論文
- 1987-01-25
著者
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田中 憲一
Faculty Of Pharmaceutical Sciences Hokuriku University
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新田 義博
School of Pharmacy, Hokuriku University
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吉藤 茂行
Faculty Of Pharmaceutical Sciences Of Hokuriku University
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田中 憲一
School of Pharmacy, Hokuriku University
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吉藤 茂行
School of Pharmacy, Hokuriku University
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新田 義博
School Of Pharmacy Hokuriku University
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Yoshifuji Shigeyuki
Faculty Of Pharmaceutical Sciences Of Hokuriku University
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