Chemical Conversion of Cyclic α-Amino Acids to α-Aminodicarboxylic Acids by Improved Ruthenium Tetroxide Oxidation

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概要

• 論文の詳細を見る

• The ruthenium tetroxide (RuO_4) oxidation of N-acylated L-proline esters, prepared from L-proline, was carried out under two-phase conditions to afford good yields of the corresponding lactams with no appreciable racemization, and the products were hydrolyzed in aqueous hydrochloric acid to L-glutamic acid. Similar transformation starting with recemic 2-piperidinecarboxylic acid and 2-azetidinecarboxylic acid gave 2-aminoadipic acid and aspartic acid, respectively. A novel chemical conversion of cyclic α-amino acids into α-aminodicarboxylic acids has been accomplished. A new solvent system, ethyl acetate-water, was developed for this two-phase oxidation. It was found to be very useful in reducing the necessary reaction time.

• 社団法人日本薬学会の論文
• 1985-12-25

著者

• 田中 憲一

  Faculty Of Pharmaceutical Sciences Hokuriku University

• 新田 義博

  School of Pharmacy, Hokuriku University

• 河合 智之

  Kotobuki Research Laboratories, Kotobuki Pharmaceutical Company, Ltd.,

• 吉藤 茂行

  Faculty Of Pharmaceutical Sciences Of Hokuriku University

• 田中 憲一

  School of Pharmacy, Hokuriku University

• 吉藤 茂行

  School of Pharmacy, Hokuriku University

• 河合 智之

  School of Pharmacy, Hokuriku University

• 河合 智之

  Kotobuki Research Laboratories Kotobuki Pharmaceutical Company Ltd.

• 新田 義博

  School Of Pharmacy Hokuriku University

• Yoshifuji Shigeyuki

  Faculty Of Pharmaceutical Sciences Of Hokuriku University

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