Chemical Conversion of L-α,ω-Diamino Acids to L-ω-Carbamoyl-α-amino Acids by Ruthenium Tetroxide Oxidation(Organic,Chemical)
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概要
- 論文の詳細を見る
Ruthenium tetroxide oxidation of N, C-protected derivatives of L-2,4-diarainobutyric acid, L-ornithine and L-lysine was carried out under two-phase conditions and the corresponding imides, formed through the oxidation of the methylene adjacent to the ω-ammo group, were obtained in good yields. Removal of the protecting groups from the products gave L-asparagine, L-glutamine and L-2-arninoadipic acid 6-amide, respectively. Thus, the first chemical conversion of L-α,ω-diamino acids into the corresponding L-ω-carbamoyl-a-amino acids without racemization has been established. L-2-Aminoadipic acid 6-amide was further converted to L-2-aminoadipic acid by acid hydrolysis. This represents a convenient method for the synthesis of L-2-aminoadipic acid starting from L-lysine.
- 社団法人日本薬学会の論文
- 1987-07-25
著者
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田中 憲一
Faculty Of Pharmaceutical Sciences Hokuriku University
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新田 義博
School of Pharmacy, Hokuriku University
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吉藤 茂行
Faculty Of Pharmaceutical Sciences Of Hokuriku University
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田中 憲一
School of Pharmacy, Hokuriku University
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吉藤 茂行
School of Pharmacy, Hokuriku University
-
新田 義博
School Of Pharmacy Hokuriku University
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Yoshifuji Shigeyuki
Faculty Of Pharmaceutical Sciences Of Hokuriku University
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