Ruthenium Tetroxide Oxidation of N-Alkyllactams(Organic,Chemical)
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概要
- 論文の詳細を見る
Ruthenium tetroxide (RuO_4) oxidation of N-alkyllactams procceded regioselectively depending on the size of lactam ring, except for the seven-membered ring. Four- and eight-membered N-methyl- and N-ethyllactams were oxidized at the exocyclic α-carbon adjacent to nitrogen to produce the N-acyllactams and NH-lactams, while five- and six-membered lactams underwent endocyclic oxidation to yield the cyclic imides. Oxidation of seven-membered lactams yielded a mixture of products arising from both exocyclic and endocyclic oxidations, These regioselectivities were confirmed in the oxidation of substrates having a tertiary carbon at the oxidation position.
- 公益社団法人日本薬学会の論文
- 1987-01-25
著者
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新田 義博
School of Pharmacy, Hokuriku University
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吉藤 茂行
Faculty Of Pharmaceutical Sciences Of Hokuriku University
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吉藤 茂行
School of Pharmacy, Hokuriku University
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荒川 由紀美
School of Pharmacy, Hokuriku University
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荒川 由紀美
School Of Pharmacy Hokuriku University
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新田 義博
School Of Pharmacy Hokuriku University
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Yoshifuji Shigeyuki
Faculty Of Pharmaceutical Sciences Of Hokuriku University
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