Ruthenium Tetroxide Oxidation of 1-Azabicycloalkan-2-ones
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概要
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The ruthenium tetroxide (RuO_4) oxidation of 1-azabicycloalkan-2-ones was investigated. The oxidation of quinolizidin-4-one (4), indolizidin-3-one (9), pyrrolizidin-3-one (11) and tetrahydro-1H, 3H-pyrrolo [1,2-c] oxazol-3-one (12) occurred at the bridgehead tertiary carbon atom and afforded the corresponding hydroxy compounds (from 11 and 12) or the imidobutyric acid derivatives (from 4 and 9). This regioselectivity is contrary to the general situation in the oxidation of N-acyl cyclic amines. However, 1-azabicyclo [4.2.0] octan-8-one (17) was oxidized at the secondary carbon atom to give the 2,8-dione (18).
- 公益社団法人日本薬学会の論文
- 1985-11-25
著者
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新田 義博
School of Pharmacy, Hokuriku University
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吉藤 茂行
Faculty Of Pharmaceutical Sciences Of Hokuriku University
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吉藤 茂行
School of Pharmacy, Hokuriku University
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荒川 由紀美
School of Pharmacy, Hokuriku University
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荒川 由紀美
School Of Pharmacy Hokuriku University
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新田 義博
School Of Pharmacy Hokuriku University
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Yoshifuji Shigeyuki
Faculty Of Pharmaceutical Sciences Of Hokuriku University
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