An Efficient Transformation of Cyclic Ene-carbamates into ω-(N-Formylamino) carboxylic Acids by Ruthenium Tetroxide Oxidation
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概要
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The ruthenium tetroxide (RuO_4) oxidation of cyclic ene-carbamates resulted in the endo-cyclic carbon-carbon double bond cleavage to afford the corresponding ω-(N-formylamino)carboxylic acids in good yields. Substituted cyclic ene-carbamates derived from (3R)-3-hydroxypiperidine hydrochloride were converted into the N-Boc 4-aminobutyric acids by utilization of the RuO_4 oxidation as the key step, which were further transformed into (3R)-4-amino-3-hydroxybutyric acid, an important key intermediate for the synthesis of L-carnitine.
- 公益社団法人日本薬学会の論文
- 2008-09-01
著者
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Sashida Haruki
Faculty Of Pharmaceutical Sciences Hokuriku University
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Yoshifuji Shigeyuki
Faculty Of Pharmaceutical Sciences Hokuriku University
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Kaname Mamoru
Faculty Of Pharmaceutical Sciences Hokuriku University
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