Synthetic Study of Optically Active 3-Azabicyclo[3.3.0]octane-2,6,8-tricarboxylic Acid
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概要
- 論文の詳細を見る
Synthesis of (1R,2S,5S,6R,8S)-3-azabicyclo[3.3.0]octane-2,6,8-tricarboxyIic acid (2) from trans-4-hydroxy-L-proline (5) was attempted. A Diels-Alder reaction of 3,4-dehydroproline derivative 9 and cyclopentadiene afforded a single stereoisomer 11. The Diels-Alder adduct was smoothly converted to the hydrochloride of 2 (24) via RuO_4 oxidation. Although some racemization of the material or product was observed during the synthetic processes, the amino acid 24 proved to be optically pure.
- 公益社団法人日本薬学会の論文
- 2003-08-01
著者
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Ohnishi M
Faculty Of Pharmaceutical Sciences Hokuriku University
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Yoshimura N
Faculty Of Pharmaceutical Sciences Hokuriku University
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ARAKAWA Yasushi
Faculty of Pharmaceutical Sciences, Hokuriku University
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YOSHIFUJI Shigeyuki
Faculty of Pharmaceutical Sciences, Hokuriku University
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Ohnishi Masafumi
Faculty of Pharmaceutical Sciences, Hokuriku University
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Yoshimura Norikazu
Faculty of Pharmaceutical Sciences, Hokuriku University
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Yoshifuji S
Faculty Of Pharmaceutical Sciences Hokuriku University
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Yoshifuji Shigeyuki
Faculty Of Pharmaceutical Sciences Hokuriku University
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Arakawa Y
Department Of Bacterial Pathogenesis And Infection Control National Institute Of Infectious Diseases
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Arakawa Yasushi
Faculty Of Pharmaceutical Sciences Hokuriku University
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YOSHIMURA Norikazu
Faculty of Engineering, Ehime University
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