Studies on Poisonous Metals. XVIII. : Effects of Several Dithiocarbamates on Tissue Distribution and Excretion of Cadmium in Rats(Envionmental)

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概要

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• The effects of various chelating agents, sodium N-benzyl-D-glucamine dithiocarbamate (NBGDTC), sodium N-p-methylbenzyl-D-glucamine dithiocarbamate (NMBGDTC), and sodium N-p-isopropylbenzyl-D-glucamine dithiocarbamate (NPBGDTC), which were newly synthesized, sodium N-methyl-D-glucamine dithiocarbamate (NMGDTC), diethyldithiocarbamate (DEDTC), dihydroxyethyldithiocarbamate (DHEDTC), and dicarboxymethyldithiocarbamate (DCMDTC), on the distribution and excretion of cadmium in rats were compared at 30 min and 24 h following cadmium injection. At 30 min after cadmium administration, these chelating agents all significantly enhanced the biliary excretion of cadmium, and at 24 h after cadmium injection, the chelating agents other than DEDTC and DCMDTC significantly enhanced the biliary excretion of the metal. The effects of NBGDTC, NMBGDTC, and NPBGDTC on the biliary excretion of cadmium were much larger than those of the other chelating agents. The urinary excretion of cadmium was increased by the chelating agents other than DEDTC and NPBGDTC. These chelating agents were effective in mobilizing cadmium from the liver, kidney, and pancreas at 30 min after treatment with cadmium. At both 30 min and 24 h after treatment with cadmium, NBGDTC, NMBGDTC, and NPBGDTC effectively depressed cadmium content in the liver without the mobilization of cadmium to the kidney. The chelating agents other than DEDTC did not result in the redistribution of cadmium to the brain, testes, lung, and heart. These results show that the injection of NBGDTC, NMBGDTC, or NPBGDTC at both 30 min and 24 h after treatment with cadmium can much more effectively mobilize cadmium from the body, mainly through the bile, without redistribution of cadmium to other tissues, such as brain, testes, lung, and heart, when compared with injection of other chelating agents. Furthermore, the pattern of mobilization and excretion of cadmium following treatment with each chelating agent was related to the organic/aqueous partition coefficient of each dithiocarbamate-cadmium complex.

• 公益社団法人日本薬学会の論文
• 1987-09-25

著者

• Ohnishi M

  Faculty Of Pharmaceutical Sciences Hokuriku University

• KOJIMA Shoji

  Laboratory of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University

• KIYOZUMI Morio

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University

• KOJIMA Shoji

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University

• Honda Toshiya

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Kojima S

  Laboratory Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University

• Kojima Shoji

  Department Of Applied Physics Faculty Of Science Tokyo University Of Education

• Kiyozumi Morio

  Faculty Of Education Kumamoto University

• Kojima Shoji

  Faculty Of Pharmaceutical Sciences Kumamoto University

• HONDA TOSHIYA

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University

• SENBA YOSHINOBU

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University

• KAMINAKA KAZUYOSHI

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University

• OHNISHI MIZUO

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University

• Ohnishi Mizuo

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University

• Honda Thoshiya

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Kaminaka Kazuyoshi

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University

• Senba Yoshinobu

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University

• Kojima Shoji

  Department Of Applied Physics Faculity Of Science Tokyo University Of Education

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