Alkylnaphthalenes. II. Tissue Accumulation of 2,6-Diisopropylnaphthalene administered continuously to Rats

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The accumulation of 2,6-diisopropylnaphthalene (2,6-DIPN) in various tissues of male and female rats was investigated by feeding a diet containing 0.1 or 0.2% 2,6-DIPN for 14-31 days. The 2,6-DIPN contents in the blood, liver, kidneys, and adipose tissue were increased in proportion to the dose, but were not affected by the difference in administration periods. The 2,6-DIPN content in the adipose tissue was much greater than that in the other tissues. In addition, the 2,6-DIPN contents in the blood, liver, and kidneys were markedly decreased in the case of administration of the control diet for 24 hr after feeding of the experimental diet for 17 or 31 days, but the decrease of 2.6-DIPN content in the adipose tissue was only 10-30%. In the case of administration of the control diet for 7 days after feeding of the experimental diet (0.1% 2,6-DIPN) for 14 days, 2,6-DIPN completely disappeared from the blood, liver, and kidneys. However, 2,6-DIPN was detected in the adipose tissue and skin even when the control diet was fed for 28-35 days after feeding of the experimental diet for 14 days.
公益社団法人日本薬学会の論文
1979-08-31