Preventive Effects of Saponins from Puerariae Radix (the root of Pueraria lobata OHWI) on in Vitro Immunological Injury of Rat Primary Hepatocyte Cultures
スポンサーリンク
概要
- 論文の詳細を見る
The preventive effects of saponins from Puerariae Radix toward in vitro immunological liver injury using an antiserum against the rat liver plasma membranes on primary cultured rat hepatocytes were studied. Crude saponin from Puerariae Radix inhibited the elevation of alanine aminotransferase (ALT) activity at the dose of 90 μg/ml. The inhibition was stronger than that of glycyrrhizin, which was a positive control drug. The representative saponins in this drug, soyasaponin I and kudzusaponin SA_3,were also more effective than glycyrrhizin, although their effects were weaker than that of crude saponin at the lower doses (90,200 μg/ml). At 500 μg/ml, kudzusaponin SA_3 showed antihepatotoxic activity equal to that of crude saponin.
- 公益社団法人日本薬学会の論文
- 1997-09-15
著者
-
ARAO Tomonori
Faculty of Pharmaceutical Sciences, Kumamoto University
-
NOHARA Toshihiro
Laboratory of Natural Medicines, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
-
Uyeda Masaru
Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un
-
Uyeda Masaru
Shokei University
-
Arao T
Faculty Of Pharmaceutical Sciences Kumamoto University
-
KINJO Junei
Laboratory of Natural Medicines, Faculty of Pharmaceutical Sciences, Kumamoto University
-
ARAO Tomonori
Laboratory of Pharmacognosy Faculty of Pharmaceutical Sciences, Kumamoto University
-
UDAYAMA Manabu
Laboratory of Pharmacognosy Faculty of Pharmaceutical Sciences, Kumamoto University
-
FUNAKOSHI Takayuki
Laboratory of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University
-
KOJIMA Shoji
Laboratory of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University
-
Nohara Toshihiro
Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University
-
Udayama Manabu
Faculty Of Pharmaceutical Sciences Kumamoto University
-
Uyeda Masaru
Department Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un
-
Kojima S
Laboratory Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University
-
Kojima Shoji
Faculty Of Pharmaceutical Sciences Kumamoto University
-
Funakoshi Takayuki
Laboratory Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University
関連論文
- Structures of Three New Oleanene Glucuronides Isolated from Lathyrus palustris var. pilosus and Hepatoprotective Activity
- A New Oleanene Glucuronide Having a Branched-Chain Sugar from Melilotus officinalis
- Oleanene-Type Triterpene Glycosides from Puerariae Radix. IV. Six New Saponins from Pueraria lobata
- Oleanene-Type Triterpene Glycosides from Puerariae Radix. III.Three New Saponins from Pueraria thomsonii
- Anti-herpes Virus Type 1 Activity of Oleanane-Type Triterpenoids(Pharmacognosy)
- A New Lignan Glycoside and Phenylethanoid Glycosides from Strobilanthes cusia BREMEK
- Fattiviracin A1, a Novel Antiviral Agent Produced by Streptomyces microflavus Strain No. 2445 II. Biological Properties
- Fattiviracin A1, a Novel Antiherpetic Agent Produced by Streptomyces microflavus Strain No. 2445 I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Elucidation
- Anti-herpes Virus Activity of Fabaceous Triterpenoidal Saponins
- Anti-herpes Virus Activity of Solanum Steroidal Glycosides
- A New Antiherpetic Agent, AH-1763 IIa, Produced by Streptomyces cyaneus Strain No. 1763
- A New Antiherpetic Agent Produced by Streptomyces sp.Strain No.758
- Structures of Fattiviracin Family, Antiviral Antibiotics
- CADMIUM, COPPER AND ZINC CONCENTRATIONS IN HUMAN RENAL CALCULUS AND GALL STONE, AND ITS ANALYTICAL IMPLICATIONS
- Partial Hydrolysis of Soyasaponin I and the Hepatoprotective Effects of the Hydrolytic Products. Study of the Structure-Hepatoprotective Relationship of Soyasapogenol B Analogs
- Preventive Effects of Saponins from Puerariae Radix (the root of Pueraria lobata OHWI) on in Vitro Immunological Injury of Rat Primary Hepatocyte Cultures
- Enhanced Production of Fattiviracins by Bacitracin-resistant Strains of Streptomyces microflavus Strain No. 2445
- Inhibitory Activities of(-)-Epigallocatechin-3-O-gallate against Topoisomerases I and II
- Topostatin, a Novel Inhibitor of Topoisomerases I and II Produced by Thermomonospora alba Strain No. 1520 III. Inhibitory Properties
- Topostatin, a Novel Inhibitor of Topoisomerases I and II Produced by Thermomonospora alba Strain No. 1520 II. Physico-chemical Properties and Structure Elucidation
- Topostatin, a Novel Inhibitor of Topoisomerases I and II Produced by Thermomonospora alba Strain No. 1520 I. Taxonomy, Fermentation, Isolation and Biological Activities
- Formation of a Chlorhexidine Degradation Intermediate through Pyruvate Incorporation by Pseudomonas sp.no.A-3
- CELL AGGREGATION FACTORS PRODUCED BY STREPTOMYCETES
- Mobilization of Renal and Hepatic Cadmium by Dithiocarbamates in Rats
- Effects of Dithiocarbamates on Tissue Distribution and Excretion of Cadmium in Mice (Proceedings of the 16 th Symposium on Environmental Pollutants and Toxicology)
- Protective Effects of Dithiocarbamates against Cadmium-Induced Testicular Damage in Rats (Proceedings of the 16 th Symposium on Environmental Pollutants and Toxicology)
- Effects of Chelating Agents on Distribution and Excretion of Inorganic Mercury in Rats (Regular Presentations) (Proceedings of the 15 th Symposium on Environmental Pollutants and Toxicology)
- Effects of Chelating Agents on Distribution and Excretion of Inorganic Mercury
- N-Long-chain Monoacylated Derivatives of 2,6-Diaminopyridine with Antiviral Activity
- Synthesis and Antiviral Activities of Some 4,4'- and 2,2'-Dihydroxytriphenylmethanes
- Synthesis and Antiviral Activities of Some 4,4'-Dihydroxytriphenylmethanes
- Synthesis of 2, 2'-Dihydroxybisphenols and Antiviral Activity of Some Bisphenol Derivatives
- Study of Structure-Hepatoprotective Relationships of Oleanene-Type Triterpenoidal Glucuronides Obtained from Several Fabaceous Plants on Rat Primary Hepatocyte Cultures
- Hepatoprotective and Hepatotoxic Actions of Oleanolic Acid-Type Triterpenoidal Glucuronides on Rat Primary Hepatocyte Cultures
- Pentalenolactone I and Hygromycin A, Immunosuppressants produced by Streptomyces filipinensis and Streptomyces hygroscopicus
- Biosynthesis of Fattiviracin FV-8,an Antiviral Agent
- Antiviral Activity of Fattiviracin FV-8 against Human Immunodeficiency Virus Type 1 (HIV-1)
- Effects of DNA on the Formation of Cell Aggregate by a Microbial Hepatoma Aggregation Factor (HAF)
- Effects of Proteases on Hepatoma AH109A Cells Aggregated by a Microbial Hepatoma Aggregation Factor (HAF)
- HAF, Hepatoma Aggregation Factor Produced by Streptomyces sp. Strain No. A-6143(Biological Chemistry)
- 3315-AF2, a Cell Aggregation Factor Produced by Streptomyces sp. Strain No.A-3315(Biological Chemistry)
- Effects of Validamycin on Glucan Synthesis by Cell-free Extracts from Rhizoctonia solani(Biological Chemistry)
- Cell Aggregation Factor Produced by Streptomyces sp. Strain No.A-3315(Biological Chemistry)
- Characteristics and Action Mechanism of SAF, Cell Aggregation Factor Produced by Streptomyces murinus Strain No.A-2805(Biological Chemistry)
- SAF, a New Cell Aggregation Factor Produced by Streptomyces murinus Strain No. A-2805(Biological Chemistry)
- Characterization of B-1625 FA_, an Acidic Actinomycin Congener(Microbiology & Fermentation Industry)
- Hepatoprotective and Hepatotoxic Activities of Sophoradiol Analogs on Rat Primary Liver Cell Cultures
- Studies on Poisonous Metals. VIII. Effects of Some Fibers on the Small Intestinal Absorption of Cadmium in Rats
- An Inhibitor of S-Hemolysin, SHI, Produced by Streptomyces sp. Strain No. 6288
- Purification and Some Properties of S-Hemolysin Produced by Streptomyces sp. Strain No. A-6288
- HPLC Profile Analysis of Oleanene-Glucuronides in Several Edible Beans
- Inhibitory Properties of Antitumor Prostaglandins against Topoisomerases(Biochemistry & Molecular Biology)
- Inhibition of Topoisomerases by Antitumor Prostaglandins.
- Alkylnaphthalenes. III. Absorption, Distribution, Accumulation, and Excretion of 2-Isopropylnaphthalene in Rats
- Interaction of Phytoestrogens with Estrogen Receptors α and β(II)
- Interaction of Phytoestrogens with Estrogen Receptors α and β
- Protective Effect of N-Benzyl-D-Glucamine Dithiocarbamate against Cadmium-Thionein-Induced Renal Damage in Rats (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
- Effects of Dithiocarbamates on Distribution and Excretion of Cadmium (Proceedings of the 14th Symposium on Environmental Pollutants and Toxicology)
- Studies on Poisonous Metals. XVIII. : Effects of Several Dithiocarbamates on Tissue Distribution and Excretion of Cadmium in Rats(Envionmental)
- Effects of Chelating Agents on Distribution and Excretion of Cadmium in Rats (Proceedings of the 12 th Symposium on Environmental Pollutants and Toxicology) (Regular Presentations)
- Photolysis and Pulmonary Toxicity of 2-Isopropylnaphthalene (Regular Presentations) (Proceedings of the 11 th Symposium on Environmental Pollutants and Toxicology)
- Identification and Determination of Urinary and Biliary Metabolites of 2-Isopropylnaphthalene in Rats
- Mechanism of the Effects of Dithiocarbamates on Excretion of Cadmium in Mice (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- Alkylnaphthalenes. II. Tissue Accumulation of 2,6-Diisopropylnaphthalene administered continuously to Rats
- Studies on Poisonous Metals. VII. Effects of Proteins and Amino Acids on the Small Intestinal Absorption of Cadmium in Rats
- Hepatoprotective Effects of Oleanene Glucuronides in Several Edible Beans
- HPLC Profile Analysis of Hepatoprotective Oleanene-Glucuronides in Several Soybean Processed Foods
- Statistical Study of Electron Avalanches in Gaseous Discharge