HAF, Hepatoma Aggregation Factor Produced by Streptomyces sp. Strain No. A-6143(Biological Chemistry)

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概要

• 論文の詳細を見る

• We searched for a new cell aggregation factor for hepatoma AH109A cells, and found one we called HAF in the culture filtrate of Streptomyces sp. strain No. A-6143 isolated from a soil sample. HAF was purified by salting-out with ammonium sulfate, DEAE-cellulose column chromatography, gel filtration on Sephadex G-100, and hydroxylapatite column chromatography. HAF was a glycoprotein which had a molecular weight of about 73,000. HAF was stable from pH 6 to 8 at 37℃ and up to 40℃ at pH 8.0, and the aggregation activity of HAF was maximum around pH 8 at 30℃. The activity was not influenced by some saccharides, but it was inhibited by EDTA and EGTA; moreover HAF activity was restored by the addition of calcium ions. HAF aggregated hepatoma AH136B and COS-7 cells as well as hepatoma AH109A cells, but it was inert to other cancer cells and human erythrocytes. These properties proved that HAF is completely different from other aggregation factors for cancer cells so far reported.

• 社団法人日本農芸化学会の論文
• 1990-08-23

著者

• Suzuki Kazuharu

  東京農業大学 農学部栄養科学科

• UYEDA Masaru

  Laboratory of Pharmaceutical Microbiology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto

• Uyeda M

  Kumamoto Univ. Kumamoto Jpn

• Uyeda Masaru

  Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Uyeda Masaru

  Shokei University

• Uyeda Masaru

  Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University

• Suzuki K

  Univ. Tokyo Tokyo

• SHIBATA Motoo

  Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University

• SUZUKI KEITAROU

  Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences Kumamoto University

• NAKANO Nahoko

  Faculty of Pharmaceutical Sciences, Kumamoto University

• SHIBATA Motoo

  Faculty of Pharmaceutical Sciences, Kumamoto University

• Suzuki Keitarou

  Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University

• Udayama Manabu

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Tominaga Hideyuki

  Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University

• NAKANO Nahoko

  Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University

• NAGATOMI Yuko

  Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University

• NAKAZONO Naoko

  Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University

• ITAI Mieko

  Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University

• Tominaga Hideyuki

  Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University

• Uyeda Masaru

  Department Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Itai Mieko

  Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University

• Nagatomi Yuko

  Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University

• Shibata Motoo

  Laboratory Of Medicinal Microbiology Faculty Of Pharmaceutical Sciences Kumamoto University

• Nakano Nahoko

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Tominaga Hiroshi

  Laboratory Of Applied Biological Science Faculty Of Agriculture

• Suzuki Kazuharu

  Department Of Nutritional Science Faculty Of Applied Bioscience Tokyo University Of Agriculture

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