Greater Effect of Dietary Potassium Tripolyphosphate than of Potassium Dihydrogenphosphate on the Nephrocalcinosis and Proximal Tubular Function in Female Rats from the Intake of a High-phosphorus Diet

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We examined whether a difference in potassium dihydrogenphosphate (KH_2PO_4) and potassium tripolyphosphate (K_5P_3O_<10>) as dietary phosphorus sources could differentially effect the nephrocalcinosis and proximal tubular function in female rats. Rats were fed on a diet containing KH_2PO_4 or K_5P_3O_<10>, at the normal phosphorus level (normal phosphorus diet) or at a high phosphorus level (high-phosphorus diet) for 21 d. Nephrocaldnosis, as confirmed by a histological examination, was apparent in all rats fed on the high-phosphorus diet, and this condition was more severe in those rats fed on K_5P_3O_<10> than in those fed on KH_2PO_4. As indicators of the proximal tubular function, the N-acetyl-β-D-glucosaminidase activity in urine and the urinary β_2-microglobulin excretion were significantly increased in those rats fed on the high-phosphorus diet containing K_5P_3O_<10>. These results indicate that the intake of a high-phosphorus diet, more strongly influenced the nephrocalcinosis and proximal tubular function when K_5P_3O_<10> rather than KH_2PO_4 was used as the dietary phosphorus source.
社団法人日本農芸化学会の論文
2001-04-23