High Phosphorus Diet Rapidly Induces Nephrocalcinosis and Proximal Tubular Injury in Rats
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概要
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The development of nephrocalcinosis and the time course of changes in kidney function, especially proximal tubular function, were studied in young male rats fed a high-phosphorus diet. The animals were fed a purified diet with a phosphorus content of either 0.5% (normal phosphorus diet) or 1.5% (high-phosphorus diet). In the group fed the high-phosphorus diet, nephrocalcinosis was found in 4 of 42 rats after 1 d of feeding and in all rats of this group at 3 d. The degree of nephrocalcinosis gradually increased with time. Upon histological ob-servation by electron microscopy, vacuoles, lysosomes and swelling of microvilli in the proximal tubules were observed in rats fed the high-phosphorus diet after 1 d of feeding. Giant lysosomes with deposition of calcium and deposition of hydroxyapatite in mitochondria were observed in the proximal tubules of rats fed the high-phosphorus diet at 3 d. Albumin concentration in the urine of these rats was signifi-cantly increased at 3 d. The activity of N-acetyl-β-D-glucosaminidase in the urine was also significantly increased after 1 d of feeding the high-phosphorus diet, and then reached a plateau. The β2-microglobulin concentration in the urine of rats fed the high-phosphorus diet was significantly increased at 14 d, and increased more toward 21 d. We concluded that nephrocalcinosis and injury to the proximal tubules are rapidly induced in rats fed a high-phosphorus diet.
- 財団法人 学会誌刊行センターの論文
著者
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KANKE Yusuke
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
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Uehara Mariko
Department Of Nutritional Science Tokyo University Of Agriculture
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Uehara Mariko
東京農業大学 農学部栄養科学科
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Uehara Mariko
Department Of Astrophysics Nagoya University
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Suzuki Kazushi
Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University:(present Addres
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Matsuzaki Hiroshi
Department Of Nutrition Junior College Of Tokyo University Of Agriculture
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Goto Shiro
Department Of Mathematic School Of Science And Technology Meiji University
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Suzuki Kazuharu
Department Of Nutritional Science Faculty Of Applied Bioscience Tokyo University Of Agriculture
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Matsuzaki Hiroshi
Department Of Applied And Environmental Chemistry Kitami Institute Of Technology
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Sato Shigeru
Central Insitute For Electron Microscopic Researche Nippon Medical School
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LIU Qiao-Ling
Central Institute for Electron Microscopic Researches
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MATSUZAKI Hiroshi
Department of Nutrition, Faculty of Agriculture
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KANKE YUSUKE
Department of Biochemistry, Tokyo College of Pharmacy
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UEHARA Mariko
Department of Nutrition, Faculty of Agriculture
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SUZUKI Kazuharu
Department of Nutrition, Faculty of Agriculture
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GOTO Shiro
Department of Nutrition, Faculty of Agriculture
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