Decreased mRNA Expression of the PTH/PTHrP Receptor and Type II Sodium-Dependent Phosphate Transporter in the Kidney of Rats Fed a High Phosphorus Diet Accompanied with a Decrease in Serum Calcium Concentration

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概要

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• This study investigates the phosphorus (P) homeostasis in the process of an altered parathyroid hormone (PTH) action in the kidney of rats fed a high P diet. Four-week-old male Wistar strain rats were fed diets containing five different P levels (0.3, 0.6, 0.9, 1.2 and 1.5%) for 21 days. The serum PTH concentration and urinary excretion of P were elevated with increasing dietary P level. Compared to rats fed the 0.3% P diet, the serum calcium (Ca) concentration remained unchanged, while the serum 1,25(OH)2D3 concentration and urinary excretion of cAMP were elevated with increasing dietary P level in rats fed the high P diets containing 0.6–0.9% P. On the other hand, a lower serum Ca concentration was observed in rats fed the high P diets containing 1.2% or greater P. The serum 1,25(OH)2D3 concentration remained unchanged in rats fed the high P diets containing 1.2% or greater P, comparison with rats fed the 0.3% P diet. The urinary excretion of cAMP and PTH/PTH-related peptide (PTHrP) receptor and type II sodium-dependent phosphate transporter (NaPi-2) mRNA in the kidney were both decreased in rats fed the high P diets containing 1.2% or greater P. In conclusion, a high P diet with subsequent decrease in serum Ca concentration suppressed the PTH action in the kidney due to PTH/PTHrP receptor mRNA down-regulation. Furthermore, an increase in the urinary excretion of P might have been caused by decreased NaPi-2 mRNA expression without the effects of PTH and 1,25(OH)2D3.

• 社団法人 日本農芸化学会の論文
• 2004-12-23

著者

• UEHARA Mariko

  Department of Astrophysics, Nagoya University

• Uehara Mariko

  Department Of Nutritional Science Tokyo University Of Agriculture

• Uehara Mariko

  東京農業大学 農学部栄養科学科

• Suzuki Kazuharu

  Department Of Nutritional Science Tokyo University Of Agriculture

• Suzuki Kazuharu

  東京農業大学 農学部栄養科学科

• KATSUMATA Shin-ichi

  Department of Nutritional Science, Tokyo University of Agriculture

• MASUYAMA Ritsuko

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• Suzuki K

  Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University

• Suzuki K

  Univ. Tokyo Tokyo

• Uehara Mariko

  Department Of Astrophysics Nagoya University

• Suzuki K

  Taisho Pharmaceutical Co. Ltd. Saitama Jpn

• Suzuki Kazushi

  Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University:(present Addres

• Suzuki Kazushi

  Department Of Agricultural Chemistry Faculty Of Agriculture Niigata University

• Suzuki K

  Department Of Nutritional Science Tokyo University Of Agriculture

• Suzuki K

  Laboratory Of Molecular Structure And Function Department Of Molecular Biology Institute Of Molecula

• Katsumata Shin-ichi

  Department Of Nutritional Science Tokyo University Of Agriculture

• Masuyama R

  Department Of Nutritional Science Faculty Of Applied Bioscience Tokyo University Of Agriculture

• Sakurai K

  Department Of Nutritional Science Tokyo University Of Agriculture

• Suzuki Kazuharu

  Department Of Nutritional Science Faculty Of Applied Bioscience Tokyo University Of Agriculture

• MASUYAMA Ritsuko

  Department of Nutrition, Faculty of Agriculture, Tokyo University of Agriculture

• SUZUKI Kazuharu

  Department of Nutrition, Faculty of Agriculture

• Masuyama Ritsuko

  Department of Molecular Bone Biology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan

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