Inhibitory Activities of(-)-Epigallocatechin-3-O-gallate against Topoisomerases I and II

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概要

• 論文の詳細を見る

• The substitution of gallic acid at the 3 position of(-)-epigallocatechin-3-O-gallate(EGCG)increased the inhibition against topoisomerase I from calf thymus gland and topoisomerase II from human placenta, and the substitution of a hydroxyl group at the 3' position increased the inhibition against the topoisomerase I. These results suggested that the 3 and 3' positions of the EGCG molecule play important roles in the process of inhibition of topoisomerase I and II. EGCG showed strong inhibition against topoisomerases I from wheat germ, calf thymus gland and Vero cells, and showed weak or no inhibition against topoisomerases I from carcinoma cells such as A549, HeLa and COLO 201 cells. EGCG differentially inhibited the topoisomerases I from different sources.

• 公益社団法人日本薬学会の論文
• 2001-09-01

著者

• Suzuki Kazuharu

  Department Of Nutritional Science Tokyo University Of Agriculture

• Suzuki Kazuharu

  東京農業大学 農学部栄養科学科

• HASHIMOTO Fumio

  Faculty of Pharmaceutical Sciences, Kumamoto University

• UYEDA Masaru

  Faculty of Medical and Pharmaceutical Sciences, Kumamoto University

• Uyeda Masaru

  Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Uyeda Masaru

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Uyeda Masaru

  Shokei University

• Shiono Yuki

  School Of Agriculture Tokai Univ.

• Udayama M

  Kumamoto Univ. Kumamoto Jpn

• SUZUKI Keitarou

  Faculty of Pharmaceutical Sciences, Kumamoto University

• YAHARA Shoji

  Graduate School of Pharmaceutical Sciences, Kumamoto University

• YAHARA Shoji

  Faculty of Pharmaceutical Sciences, Kumamoto University

• Suzuki K

  Univ. Tokyo Tokyo

• Suzuki K

  Taisho Pharmaceutical Co. Ltd. Saitama Jpn

• Suzuki Keitarou

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Suzuki Kazushi

  Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University:(present Addres

• Suzuki K

  Department Of Nutritional Science Tokyo University Of Agriculture

• Udayama Manabu

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Uyeda Masaru

  Department Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Hashimoto Fumio

  Faculty Of Agriculture Kagoshima University

• Yahara S

  Kumamoto Univ. Kumamoto Jpn

• Yahara Shoji

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Yahara Shoji

  Graduate School Of Pharmaceutical Sciences Kumamoto University

• Sakurai K

  Department Of Nutritional Science Tokyo University Of Agriculture

• Hashimoto Fumio

  Faculity Of Science Osaka City University

• Yahara Shoji

  Graduate School Of Pharmaceutical Sciences Kumamoto Univ.

• Suzuki Kazuharu

  Department Of Nutritional Science Faculty Of Applied Bioscience Tokyo University Of Agriculture

• Hashimoto Fumio

  Faculty of Agriculture, Kagoshima University

• Yahara Shoji

  Faculty of Medical and Pharmaceutical Sciences, Kumamoto University

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