Synthesis and Antiviral Activities of Some 4,4'- and 2,2'-Dihydroxytriphenylmethanes

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概要

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• We synthesized some 4,4'-and 2,2'-dihydroxytriphenylmethane derivatives 3a-e and 4a-c by condensation of phenol 1 and aromatic aldehyde 2 in moderate to good yields (30-83%). Most of them showed significant antiviral activity against herpes simplex virus type 1 (anti-HSV-1 activity) in a plaque reduction assay. The most potent antiviral activity (EC_<50>=0.79μg/ml) was observed in the 4,4'-dihydroxytriphenylmethane derivative 3b. This compound 3b showed lower cytotoxicity (CC_<50>=30.2μg/ml), compared to that of the prototype 3a.

• 公益社団法人日本薬学会の論文
• 2005-09-01

著者

• Mibu N

  Faculty Of Pharmaceutical Sciences Fukuoka University

• YOKOMIZO Kazumi

  Faculty of Medical and Pharmaceutical Sciences, Kumamoto University

• UYEDA Masaru

  Faculty of Medical and Pharmaceutical Sciences, Kumamoto University

• Uyeda Masaru

  Dep. Of Nutrition Sci. Facultiy Of Living Sci. Shokei Univ.

• Uyeda Masaru

  Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Uyeda Masaru

  Shokei University

• Yokomizo K

  Kumamoto Univ. Kumamoto Jpn

• Udayama M

  Kumamoto Univ. Kumamoto Jpn

• Mibu Nobuko

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Yokomizo Kazumi

  Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Yokomizo Kazumi

  Faculty Of Pharmaceutical Sciences Kumamoto University

• SUMOTO Kunihiro

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Udayama Manabu

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Uyeda Masaru

  Department Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un

• Sumoto K

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Sumoto Kunihiro

  Fukuoka Univ. Fukuoka Jpn

• Sumoto Kunihiro

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Sumoto Kunihiro

  Faculty of Pharmaceutical Science, Fukuoka University

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