Microbial Degradation of Disinfectants : Two New Aromatic Degradation Products of Chlorhexidine, Chlorhexidine Aromatic Degradation Product (CHADP)-4 and CHADP-6, Produced by Pseudomonas sp. Strain No. A-3
スポンサーリンク
概要
- 論文の詳細を見る
To clarify the degradation pathway of chlorhexidine by a microbe, Pseudomonas sp. Strain No. A-3, the isolation and identification of microbial chlorhexidine degradation products were attempted. Two aromatic degradation products of chlorhexidine, named chlorhexidine aromatic degradation product (CHADP)-4 and CHADP-6, were isolated by column chromatography using Diaion HP-10, and purified by column chromatography using Diaion HP-20SS and Sephadex LH-20. The chemical structures of both compounds were examined by infrared, ^1H NMR, ^<13>C NMR and fast atom bombardment (FAB) mass spectra studies. Based on the spectroscopic data, CHADP-4 (molecular weight 335) and CHADP-6 (molecular weight 377) were found to be direct degradation products of chlorhexidine and were thought to be cleavage partners of p-chlorophenylurea (CHADP-5) and p-chloraniline (p-CA), respectively. Antimicrobial activity of CHADP-6 are similar to that of chlorhexidine, but antimicrobial activity of CHADP-4 decreased to 1/5-1/10 that of chlorhexidine.
- 公益社団法人日本薬学会の論文
- 2006-02-01
著者
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高濱 和夫
熊本大学 大学院医学薬学研究部 環境分子保健学
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Yokoi Kaori
School Of Agriculture Kyushu Tokai University
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Yokomizo K
Kumamoto Univ. Kumamoto Jpn
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Takahama K
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University
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Yokomizo Kazumi
Laboratory Of Pharmaceutical Microbiology Faculty Of Medical And Pharmaceutical Sciences Kumamoto Un
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Yokomizo Kazumi
Faculty Of Pharmaceutical Sciences Kumamoto University
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Takeda K
Division Of Instrumental Analysis Institute Of Resource Development And Analysis Kumamoto University
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Kido Y
Div. Of Instrumental Analysis Inst. Of Resource Dev. And Analysis Kumamoto Univ.
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Nakano Satoko
Division Of Instrumental Analysis Institute Of Resource Development And Analysis Kumamoto University
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Tanaka Teruo
Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto Universi
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Ishii Midori
Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto Universi
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Mori Yuka
Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto Universi
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Yano Yohko
Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto Universi
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Iijima Tomonori
Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto Universi
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Takeda Katsushi
Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto Universi
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Kido Yutaka
Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto Universi
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Iijima Tomonori
Div. Of Instrumental Analysis Inst. Of Resource Dev. And Analysis Kumamoto Univ.
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Mori Yuka
Division Of Instrumental Analysis Institute Of Resource Development And Analysis Kumamoto University
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Tanaka Teruo
熊本大学生命資源研究･支援センター 機器分析分野
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Yano Yohko
Division Of Instrumental Analysis Institute Of Resource Development And Analysis Kumamoto University
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Ishii Midori
Division Of Instrumental Analysis Institute Of Resource Development And Analysis Kumamoto University
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Kido Y
Faculty Of Pharmaceutical Sciences Kumamoto University
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Kido Y
Ube Research Laboratory Fujirebio Inc.
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Tanaka Teruo
Division of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto University
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