Prenatal Exposure to a Low Dose of 4-Hydroxy-2',3,3',4',5'-Pentachlorobiphenyl Increases Emotional Behaviors in Mice
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概要
- 論文の詳細を見る
Hydroxylated polychlorinated biphenyl (OH-PCB) is a major metabolite of PCB, which is an endocrine disruptor. In this study, we investigated the neurobehavioral effects of prenatal exposure to a very low dose of OH-PCB (4-hydroxy-2',3,3',4',5'-pentachlorobiphenyl, 4-OH-pentaCB) in mice. 4-OH-pentaCB, dissolved in corn oil, was orally given at 0.1μg/30μl/animal/day to pregnant mice from gestation days 11 to 17. In the open field test, the number of ambulation and rearing drastically increased among 4-OH-pentaCB exposed mice compared with the control. However, 4-OH-pentaCB exposure had no effect on passive avoidance. These results suggest that an extremely low dose of 4-OH-pentaCB may selectively disrupt neurobehavioral functions involved in ambulation and rearing in mice.
- 公益社団法人日本薬学会の論文
- 2005-08-01
著者
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高濱 和夫
熊本大学 大学院医学薬学研究部 環境分子保健学
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白崎 哲哉
熊本大学 大学院医学薬学研究部 環境分子保健学
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副田 二三夫
熊本大学 大学院医学薬学研究部 環境分子保健学
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TAKAHAMA Kazuo
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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Takahama K
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University
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Takahama Kazuo
Department Of Electrical Engineering Faculty Of Engineering Toyo University
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SOEDA FUMIO
Department of Clinical Pharmacy, Oita Medical University
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Kaitsuka Taku
Department of Environmental and Molecular Health Sciences, Graduate School of Pharmaceutical Science
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Shirasaki Tetsuya
Department of Environmental and Molecular Health Sciences, Graduate School of Pharmaceutical Science
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Soeda Fumio
Department Of Clinical Pharmacy Oita Medical University
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Kaitsuka Taku
Department Of Environmental And Molecular Health Sciences Graduate School Of Pharmaceutical Sciences
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TAKAHAMA Kazuo
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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