METABOLITES OF PIPERIDINE IN RAT URINE
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概要
- 論文の詳細を見る
Piperidine is one of pharmacologically active biogenic amines While two pathways for piperidine production have been reported, little is known about metabolism of the compound. In the present study, piperidine and its hydroxylated, conjugated and unknown metabolites were detected in rat urine by radiochromatographic analysis. Using GC-MS technique, it was confirmed that 3-hydroxypiperidine and 4-hydroxypiperidine are major metabolites of piperidine of either exogenous or endogenous origin. The findings substantiate the existence of a mechanism which inactivates piperidine in the living body, since both metabolites lack the potent pharmacological activities as those induced by piperidine.
- 社団法人 日本薬理学会の論文
著者
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Okano Yoshiro
Department Of Pharmacological Sciences Faculty Of Pharmaceutical Sciences Kumamoto University
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TAKAHAMA Kazuo
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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MIYATA Takeshi
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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KASE YOSHITOSHI
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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Takahama Kazuo
Department Of Electrical Engineering Faculty Of Engineering Toyo University
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MOTOYA TOshiro
Department of Clinival Pharmacy and Department of Anatomy, Faculty of Medicine, Kagoshima University
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Okano Yoshiro
Department Of Pharmaceutical Care And Clinical Pharmacy Faculty Of Pharmaceutical Sciences Tokushima
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HUNG Shiang-Huey
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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KATAOKA Mikiko
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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Miyata Takeshi
Department Of Chemico-pharmacological Sciences Graduate School Of Pharmaceutical Sciences Kumamoto U
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MOTOYA Toshiro
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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MIYATA Takeshi
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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OKANO Yoshiro
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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TAKAHAMA Kazuo
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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