Effects of SS320A, a New Cysteine Derivative, on the Change in the Number of Goblet Cells Induced by Isoproterenolin Rat Tracheal Epithelium
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概要
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We examined the effects of SS320A ((-)-(R)-2-amino-3-(3-hydroxypropylthio)propionic acid), a new cysteine derivative, on the change in the number of goblet cells induced by isoproterenol in rat tracheal epithelium. Four types of goblet cells were characterized in tracheal epithelium according to their size and staining affinity with Alcian blue (AB) / periodic acid Schiff (PAS). When each rat was given a single daily injection of isoproterenol (0.05 mg/kg, i.p.) for 14 days, a significant increase was observed in AB/PAS-positive cells that were recognizable as goblet cells in tracheal epithelium. When SS320A (10 - 100 mg/kg, p.o.) or propranolol (1 mg/kg, s.c.) was administered before each injection of isoproterenol, the increase in the number of goblet cells induced by isoproterenol was significantly inhibited. There was no difference between male and female rats with regard to this inhibitory action. On the other hand, ambroxol, bromhexine, L-cysteine ethyl ester and S-carboxymethylcysteine (100 mg/kg, p.o., respectively), which are used as expectorants, had no inhibitory effects on the isoproterenol-induced change in the number of goblet cells. Four metabolites (M1 - M4) of SS320A in rats also failed to inhibit the change induced by isoproterenol. These data suggest that SS320A itself may have a beneficial effect against mucus hypersecretion in chronic respiratory diseases.
- 社団法人 日本薬理学会の論文
- 1998-05-01
著者
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Isohama Yoichiro
Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto
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高濱 和夫
熊本大学 大学院医学薬学研究部 環境分子保健学
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KAI Hirofumi
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate R
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礒濱 洋一郎
熊本大学薬学部薬物活性学講座
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礒浜 洋一郎
熊本大学大学院医学薬学研究部薬物活性学分野
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礒濱 洋一郎
熊本大学大学院医学薬学研究部・薬物活性学分野
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Mizuno Hiroyuki
エスエス製薬中央研究所
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TAKAHAMA Kazuo
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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MIYATA Takeshi
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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宮田 健
熊本大学大学院医学薬学研究部薬物活性学分野
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Kai Hirofumi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kumamoto University
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Takahama K
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University
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Takahama Kazuo
Department Of Electrical Engineering Faculty Of Engineering Toyo University
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Miyata T
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kumamoto University
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Isohama Yoichiro
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kumamoto University
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TAKAHASHI Koichi
Central Research Laboratories, SS Pharmaceutical Co., Ltd.
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MIZUNO Hiroyuki
Central Research Laboratories, SS Pharmaceutical Co., Ltd.
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OHNO Hiromitsu
Central Research Laboratories, SS Pharmaceutical Co., Ltd.
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NAGAOKA Shigeru
Japan Research Institute of Sputum
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Ohno Hiromitsu
Central Research Laboratories Ss Pharmaceutical Co. Ltd.
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Kai Hirofumi
Department Of Molecular Medicine Faculty Of Pharmaceutical Sciences Kumamoto University
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Mizuno Hiroyuki
Central Research Laboratories Ss Pharmaceutical Co. Ltd.
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Isohama Yoichiro
Department Of Chemico-pharmacological Sciences Graduate School Of Pharmaceutical Sciences Kumamoto U
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Miyata Takeshi
Department Of Chemico-pharmacological Sciences Graduate School Of Pharmaceutical Sciences Kumamoto U
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Miyata Takeshi
Department Of Chemico-pharmacology Faculty Of Pharmaceutical Sciences Kumamoto University
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Takahashi Koichi
Central Research Laboratories Ssp Co. Ltd.
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TAKAHAMA Kazuo
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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