Non-competitive Inhibition of Kainate-Induced Currents by Diethylstilbestrol in Acutely Isolated Mouse CA1 Hippocampal Neurons

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概要

• 論文の詳細を見る

• The effect of a synthetic estrogen, diethylstilbestrol(DES), on kainate−induced currents was investigated in the hippocampal CA1 pyramidal neurons acutely dissociated from the mice using the nystatin−perforated patch−clamp recording configuration under voltage−clamp conditions.DES inhibited the current evoked by 100μM kainate in a concentration−dependent manner with a half−maximum inhibitory concentration of 8.8μM.The action of DES was voltage−independent.Since DES produced a suppression of the maximum response of the kainate concentration−response curve, the inhibition by DES of the kainate−induced current appears to be non−competitive.

• 社団法人 日本薬理学会の論文
• 2000-10-01

著者

• Shimada Hideaki

  Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu Universi

• TAKAHAMA Kazuo

  Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

• Takahama Kazuo

  Department Of Electrical Engineering Faculty Of Engineering Toyo University

• Takahama Kazuo

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University

• Shimada Hideaki

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University

• ISHIBASHI Hitoshi

  Department of Physiology, Graduate School of Medical Sciences, Kyushu University

• Shimada Hideaki

  Department Of Academic Surgery Graduate School Of Medicine Chiba University

• OKUYA Satoshi

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University

• Okuya Satoshi

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University

• Shimada Hideaki

  Department Of Academic Surgery (m9) Graduate School Of Medicine Chiba University

• Ishibashi Hitoshi

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University

• TAKAHAMA Kazuo

  Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University

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