Protective effect of surface-active phospholipids against the acid-inducing inhibition of the tracheal mucociliary transport.
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概要
- 論文の詳細を見る
Little is known about the physiological role of surface active phospholipids (SAP) in the central respiratory tract. In the present study, the effect of SAP on acid-inducing inhibition of particle transport by the tracheal mucociliary function was investigated in unanesthetized pigeons. SAP and acids were directly nebulized to the surface of the trachea. The composition of SAP was based on that of the pulmonary surfactant. The experiment was carried out under application of acetylcholine providing a constant mucociliary transport. SAP significantly diminished HCl- and H<SUB>2</SUB>SO<SUB>4</SUB>-inducing inhibitions of the mucociliary transport. Benzalkonium chloride also reduced the inhibition. The results suggest that SAP may be a protecting factor of the mucociliary clearance and that SAP may be connected with hydrophobicity not only of the alveolar surface but of the tracheal epithelium.
- 公益社団法人 日本薬理学会の論文
著者
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Oda Yoshiaki
Department Of Agricultural Chemistry Yamagata University
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Kai Hirofumi
Department Of Molecular Medicine Faculty Of Pharmaceutical Sciences Kumamoto University
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Miyata Takeshi
Department Of Chemico-pharmacological Sciences Graduate School Of Pharmaceutical Sciences Kumamoto U
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OKANO Yoshiro
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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TAKAHAMA Kazuo
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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SAITO Munetoshi
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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FURUSAWA Ken-ichi
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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OKANO Yoshiro
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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