Antimicrobial Effects of Drugs against Multidrug-Resistant Pseudomonas aeruginosa(Microbiology)
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概要
- 論文の詳細を見る
We evaluated the effects of antimicrobial drugs on four strains of Pseudomonas aeruginosa that are resistant to eight widely used antipseudomonal drugs (piperacillin, piperacillin-tazobactam, imipenem, meropenem, ceftazidime, aztreonam, amikacin, ciprofloxacin) and colistin. In the killing test, colistin (2μg/ml) was the most effective, followed by aztreonam (48μg/ml), piperacillin-tazobactam (192-4μg/ml), piperacillin (192μg/ml), and a three drug combination of azetreonam (16μg/ml), ceftazidime (16μg/ml), and amikacin (4μg/ml). Six hours after drug addition, colistin (2μg/ml), aztreonam (48μg/ml), piperacillin-tazobactam (192-4μg/ml), piperacillin (192μg/ml), and the above three drug combination had bacteriostatic effects on all four strains. Colistin, three time breakpoint of aztreonam, piperacillin, or piperacillin-tazobactam, and the three drug combination of aztreonam, ceftazidime, and amikacin were effective in vitro.
- 公益社団法人日本薬学会の論文
- 2008-10-01
著者
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MAEDA Kumiko
Department of Medicine, Cardiovascular Division, Osaka Ekisaikai Hospital
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Maeda Kumiko
Department Of Pharmacy Yamaguchi University Hospital
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OIE Shigeharu
Department of Pharmacy, Yamaguchi University Hospital
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KAMIYA Akira
Department of Pharmacy, Yamaguchi University Hospital
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Kamiya Akira
山口大学医学部附属病院 薬剤部
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Okano Yoshiro
Department Of Pharmacological Sciences Faculty Of Pharmaceutical Sciences Kumamoto University
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Oie Shigeharu
Yamaguchi Univ. Hospital Ube Jpn
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Oie Shigeharu
Department Of Pharmacy Yamaguchi University Hospital
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Ishida Shiro
Tokushima Bunri Univ. Tokushima Jpn
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KOBAYASHI Youko
Department of Pharmacy, Yamaguchi University Hospital
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ISHIDA Shiro
Department of Pharmaceutical Care and Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Tokushi
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KOBAYASHI Toshihiko
Clinical Laboratory, Yamaguchi University Hospital
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SHIKICHI Kyoko
Clinical Laboratory, Yamaguchi University Hospital
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MIZUNO Hidekazu
Clinical Laboratory, Yamaguchi University Hospital
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Kamiya Akira
Department Of Biomedical Engineering University Of Tokyo
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Ishida Shiro
Department Of Pharmaceutical Care And Clinical Pharmacy Faculty Of Pharmaceutical Sciences Tokushima
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Okano Yoshiro
Tokushima Bunri Univ. Tokushima Jpn
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Okano Yoshiro
Department Of Pharmaceutical Care And Clinical Pharmacy Faculty Of Pharmaceutical Sciences Tokushima
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Shikichi Kyoko
Clinical Laboratory Yamaguchi University Hospital
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Mizuno Hidekazu
Clinical Laboratory Yamaguchi University Hospital
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Kobayashi Youko
Department Of Pharmacy Yamaguchi University Hospital
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Kobayashi Toshihiko
Clinical Laboratory Yamaguchi University Hospital
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Maeda Kumiko
Department Of Medicine Osaka Ekisaikai Hospital
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OKANO Yoshiro
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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