Disinfection Methods for Spores of Bacillus atrophaeus, B. anthracis, Clostridium tetani, C. botulinum and C. difficile
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概要
- 論文の詳細を見る
To evaluate disinfection methods for environments contaminated with bioterrorism-associated microorganism (Bacillus anthracis), we performed the following experiments. First, the sporicidal effects of sodium hypochlorite on spores of five bacterial species were evaluated. Bacillus atrophaeus was the most resistant to hypochlorite, followed in order by B. anthracis, Clostridium botulinum and Clostridium tetani, and Clostridium difficile. Subsequently, using B. atrophaeus spores that were the most resistant to hypochlorite, the sporicidal effects of hypochlorite at lower pH by adding vinegar were evaluated. Hypochlorite containing vinegar had far more marked sporicidal effects than hypochlorite alone. Cleaning with 0.5% (5000 ppm) hypochlorite containing vinegar inactivated B. atrophaeus spores attached to vinyl chloride and plywood plates within 15 s, while that not containing vinegar did not inactivate spores attached to cement or plywood plates even after 1 h. Therefore, the surfaces of cement or plywood plates were covered with gauze soaked in 0.5% hypochlorite containing vinegar, and the sporicidal effects were evaluated. B. atrophaeus spores attached to plywood plates were not inactivated even after 6 h, but those attached to cement plates were inactivated within 5 min. On the other hand, covering the surfaces of plywood plates with gauze soaked in 0.3% peracetic acid and gauze soaked in 2% glutaral inactivated B. atrophaeus spores within 5 min and 6 h, respectively. These results suggest that hypochlorite containing vinegar is effective for disinfecting vinyl chloride, tile, and cement plates contaminated with B. anthracis, and peracetic acid is effective for disinfecting plywood plates contaminated with such microorganism.
- 公益社団法人 日本薬学会の論文
著者
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Oie Shigeharu
Department Of Pharmacy Yamaguchi University Hospital
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Kawamoto Keiko
Laboratory Of Food Microbiology & Immunology Research Center For Animal Hygiene And Food Safety
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Makino Sou-ichi
Laboratory Of Food Microbiology & Immunology Research Center For Animal Hygiene And Food Safety
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Furukawa Hiroyuki
Department Of Electronics Nagoya University
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Obayashi Akiko
Department Of Pharmacy Yamaguchi University Hospital
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Yamasaki Hirofumi
Department of Pharmacy, Yamaguchi University Hospital
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Kenri Tsuyoshi
Laboratory of Bacterial Toxins, Toxoids and Antitoxins, Department of Bacteriology II, National Inst
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Takahashi Motohide
Laboratory of Bacterial Toxins, Toxoids and Antitoxins, Department of Bacteriology II, National Inst
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Kenri Tsuyoshi
Laboratory of Bacterial Toxins, Toxoids and Antitoxins, Department of Bacteriology II, National Institute of Infectious Diseases
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Makino Sou-ichi
Laboratory of Food Microbiology and Immunology, Research Center for Animal Hygiene and Food Safety, Obihiro University of Agriculture and Veterinary Medicine
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Takahashi Motohide
Laboratory of Bacterial Toxins, Toxoids and Antitoxins, Department of Bacteriology II, National Institute of Infectious Diseases
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