Microbial Contamination of Nebulization Solution and Its Measures(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
We evaluated the microbial contamination of nebulization solutions in medication cups from a total of 76 ultrasonic nebulizers in use in 10 hospitals. In addition, an interview survey was given to nurses to evaluate the disinfection methods of these ultrasonic nebulizers. Of a total of 76 nebulization solution samples, 11 (14.5%) were contaminated with 10-10^2 colony-forming units (CFU)/ml and 9 (11.8%) with 10^3-10^5 CFU/ml. The major contaminants were glucose non-fermentative bacilli such as Burkholderia cepacia, CDC gr.IV C-2, and Sphin-gomonas paucimobilis. Comparison of microbial contamination between the frequencies of disinfection showed a significantly lower number of contaminated samples when the cups were disinfected once daily than when disinfected once at intervals of 2-7 d (p=0.00037). In addition, comparison between the presence and absence of preservatives contained in the nebulization solution showed a significantly lower number of contaminated samples in the presence, rather than in the absence, of preservatives (p=0.00001). These results show that disinfection of ultrasonic nebulizers at 24-h intervals is desirable. In particular, when nebulization solutions not containing preservatives are used, disinfection at 24-h intervals is indispensable.
- 公益社団法人日本薬学会の論文
- 2006-03-01
著者
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OIE Shigeharu
Department of Pharmacy, Yamaguchi University Hospital
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KAMIYA Akira
Department of Pharmacy, Yamaguchi University Hospital
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Kamiya Akira
山口大学医学部附属病院 薬剤部
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Okano Yoshiro
Department Of Pharmacological Sciences Faculty Of Pharmaceutical Sciences Kumamoto University
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Oie Shigeharu
Yamaguchi Univ. Hospital Ube Jpn
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Oie Shigeharu
Department Of Pharmacy Yamaguchi University Hospital
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Ishida Shiro
Tokushima Bunri Univ. Tokushima Jpn
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ISHIDA Shiro
Department of Pharmaceutical Care and Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Tokushi
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Kamiya Akira
Department Of Biomedical Engineering University Of Tokyo
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Ishida Shiro
Department Of Pharmaceutical Care And Clinical Pharmacy Faculty Of Pharmaceutical Sciences Tokushima
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Okano Yoshiro
Tokushima Bunri Univ. Tokushima Jpn
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Okano Yoshiro
Department Of Pharmaceutical Care And Clinical Pharmacy Faculty Of Pharmaceutical Sciences Tokushima
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MAKIEDA Daiki
Department of Pharmacy, Yamaguchi University Hospital
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Makieda Daiki
Department Of Pharmacy Yamaguchi University Hospital:department Of Pharmaceutical Care And Clinical
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OKANO Yoshiro
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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