Increased Production and/or Secretion of Pulmonary Surfactant in Rats by Long Term Sulfur Dioxide Exposure
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概要
- 論文の詳細を見る
Influence of long term SO_2 exposure on the pulmonary surfactant in rats was studied by means of chemical analysis and microscopic verification. At a time after termination of the exposure period, the general symptom in rats was similar to that of bronchitis. The content of disaturated phosphatidylcholine, a main functional component of the pulmonary surfactant, significantly increased not only in broncho-alveolar lavage fluid but also in pulmonary microsomal fraction by long term SO_2 exposure. Microscopic verification of alveolar type II cells from the bronchitic rats demonstrated the development of rough surface endoplasmic reticulums and an increase of the number of osmiophillic bodies. The results suggest that pulmonary surfactant production and/or secretion are activated in rats with bronchitis caused by long term SO_2 exposure.
- 社団法人日本薬学会の論文
著者
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Isohama Yoichiro
Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto
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KAI Hirofumi
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate R
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礒濱 洋一郎
熊本大学薬学部薬物活性学講座
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礒浜 洋一郎
熊本大学大学院医学薬学研究部薬物活性学分野
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Okano Yoshiro
Department Of Pharmacological Sciences Faculty Of Pharmaceutical Sciences Kumamoto University
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ODA Yoshiaki
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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TAKAHAMA Kazuo
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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MIYATA Takeshi
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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宮田 健
熊本大学大学院医学薬学研究部薬物活性学分野
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Oda Yoshiaki
Department Of Agricultural Chemistry Yamagata University
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Kai Hirofumi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kumamoto University
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Takahama K
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University
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Takahama Kazuo
Department Of Electrical Engineering Faculty Of Engineering Toyo University
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Miyata T
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kumamoto University
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Okano Yoshiro
Department Of Pharmaceutical Care And Clinical Pharmacy Faculty Of Pharmaceutical Sciences Tokushima
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Kai Hirofumi
Department Of Molecular Medicine Faculty Of Pharmaceutical Sciences Kumamoto University
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Isohama Yoichiro
Department Of Chemico-pharmacological Sciences Graduate School Of Pharmaceutical Sciences Kumamoto U
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Miyata Takeshi
Department Of Chemico-pharmacological Sciences Graduate School Of Pharmaceutical Sciences Kumamoto U
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Miyata Takeshi
Department Of Chemico-pharmacology Faculty Of Pharmaceutical Sciences Kumamoto University
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OKANO Yoshiro
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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TAKAHAMA Kazuo
Department of Chemico-Pharmacology, Faculty of Pharmaceutical Sciences, Kumamoto University
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