Inhibitory Effects of Fruit Juices on Cytochrome P450 2C9 Activity in Vitro
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概要
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There is limited information on the effect of fruits on human cytochrome P450 (CYP) 2C9 activity. The objective of this study was to determine the effect of fruit juice on CYP2C9-mediated drug metabolism. Nine citrus fruits and eight tropical fruits were chosen. We investigated effects of the fruits on diclofenac 4′-hydroxylation and tolbutamide hydroxylation by human liver microsomes. Among the fruits, pineapple juice showed potent inhibition of CYP2C9 activity. The addition of 25 μl (5.0% v/v) of pineapple juice resulted in almost complete inhibition. Next we examined the inhibitory effect of bromelain, a cysteine protease in pineapple. Bromelain also strongly inhibited CYP2C9 activity. In addition, E-64, a cysteine protease inhibitor, almost entirely blocked inhibition by pineapple juice and bromelain. Thus we found that pineapple juice was a potent inhibitor of CYP2C9, and that the inhibitory effect might be due to the bromelain contained in pineapple.
- 社団法人 日本農芸化学会の論文
著者
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KAI Hirofumi
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate R
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SEKIYA Hiroshi
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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Okumura Manabu
Department Of Pharmacy Miyazaki Medical College Hospital
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ARIMORI Kazuhiko
Department of Pharmacy, Miyazaki Medical College Hospital
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Hidaka Muneaki
Department Of Pharmacy Miyazaki Medical College Hospital
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Nagata Masashi
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare:department Of Pharmacy Fac
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Kawano Yohei
Department Of Pharmacy Faculty Of Medicine University Of Miyazaki Hospital
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YAMASAKI Keishi
Department of Pharmacy, Miyazaki Medical College Hospital
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HIDAKA Muneaki
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
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