Local Anti-inflammatory Activity and Systemic Side Effects of NM-135, a New Prodrug Glucocorticoid, in an Experimental Inflammatory Rat Model

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概要

• 論文の詳細を見る

• The local anti-inflammatory activity and systemic side effects of NM-135 (6α, 9-difluoro-11β-hydroxy-16α-methyl-21[[2, 3, 4, 6-tetrakis-O-(4-methylbenzoyl)-β-D-glucopyranosyl]oxy]-pregna-1, 4-diene-3, 20-dione) in croton oil-induced granuloma pouches and ear edema in rats were studied. The local anti-inflammatory activity of NM-135 was stronger than that of betamethasone 17-valerate (BV). As to systemic side effects, BV and diflucortolon valerate (DFV) caused thymolysis at the doses required for the anti-inflammatory activity. In contrast, no clear systemic side effect was observed in rats administered NM-135 at the dose producing the anti-inflammatory activity. These results suggest that NM-135 is a drug exhibiting a high degree of dissociation between the local anti-inflammatory activity and systemic side effects.

• 社団法人 日本薬理学会の論文
• 1998-12-01

著者

• KAI Hirofumi

  Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Global COE Cell Fate R

• MIYATA Takeshi

  Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University

• Kai Hirofumi

  Department Of Pharmacological Sciences Faculty Of Pharmaceutical Sciences Kumamoto University

• Tashiro Manabu

  Division Of Cyclotron Nuclear Medicine Cyclotron And Radioisotope Center Tohoku University

• Miyata T

  Kumamoto Univ. Kumamoto Jpn

• Ishii Toshiaki

  岐阜大学 大学院連合獣医学研究科病態獣医学連合講座

• Ishii Toshiaki

  Department Of Pathogenetic Veterinary Science The United Graduate School Of Veterinary Sciences Gifu

• Ishii Toshiaki

  Department Of Pathobiological Science Obihiro University Of Agriculture And Veterinary Medicine

• Kijima-suda Isao

  Tokyo Pharmaceutical Research Laboratories Nissin Food Products Co. Ltd.

• Ishii T

  The Department Of Pulmonary Medicine Yokohama City University Medical Center

• Tashiro Manabu

  Tohoku Univ. Miyagi Jpn

• ISHII Takayuki

  Tokyo Pharmaceutical Research Laboratories, Nissin Food Products Co., Ltd.

• KIBUSHI Nobuyuki

  Tokyo Pharmaceutical Research Laboratories, Nissin Food Products Co., Ltd.

• NAKAJIMA Takashi

  Tokyo Pharmaceutical Research Laboratories, Nissin Food Products Co., Ltd.

• KAKUTA Tae

  Tokyo Pharmaceutical Research Laboratories, Nissin Food Products Co., Ltd.

• TANAKA Noriko

  Tokyo Pharmaceutical Research Laboratories, Nissin Food Products Co., Ltd.

• SATO Chiaki

  Tokyo Pharmaceutical Research Laboratories, Nissin Food Products Co., Ltd.

• SUGAI Kei

  Tokyo Pharmaceutical Research Laboratories, Nissin Food Products Co., Ltd.

• Kai Hirofumi

  Department Of Molecular Medicine Faculty Of Pharmaceutical Sciences Kumamoto University

• Sugai Kei

  Tokyo Pharmaceutical Research Laboratories Nissin Food Products Co. Ltd.

• Kakuta Tae

  Tokyo Pharmaceutical Research Laboratories Nissin Food Products Co. Ltd.

• Ido Tatsuo

  Division Of Nuclear Pharmacology Cyclotron Radioisotope Center Tohoku University

• Miyata T

  Division Of Cyclotron Nuclear Medicine Cyclotron And Radioisotope Center Tohoku University

• Sato Chiaki

  Tokyo Pharmaceutical Research Laboratories Nissin Food Products Co. Ltd.

• Miyata Takeshi

  Department Of Chemico-pharmacological Sciences Graduate School Of Pharmaceutical Sciences Kumamoto U

• Kibushi Nobuyuki

  Tokyo Pharmaceutical Research Laboratories Nissin Food Products Co. Ltd.

• Nakajima Takashi

  Tokyo Pharmaceutical Research Laboratories Nissin Food Products Co. Ltd.

• Tanaka Noriko

  Tokyo Pharmaceutical Research Laboratories Nissin Food Products Co. Ltd.

• SATO Chiaki

  Tokyo Institute of Technology

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