Pharmacology of Airway Goblet Cell Mucin Release
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概要
- 論文の詳細を見る
Airway mucus hypersecretion is one of the major clinical manifestations of patients suffering from various pulmonary diseases. However, no drugs are yet available to control airway mucus hypersecretion. For the past 15 years, a plethora of information has amassed with regard to the pharmacology of airway goblet cell mucin secretion using various primary cell culture systems. The recent discovery of various MUC genes has also greatly stimulated research in this field. Nevertheless, the heterogeneity of the oligosaccharide structure of mucin molecules makes it extremely difficult to assess the significance of the information derived from the pharmacological studies. Therefore, it seems crucially important to understand the roles of individual mucins in conjunction with normal airway physiology and pathology, which should be the future research directions necessary for studying airway goblet cell mucin pharmacology.
- 社団法人 日本薬理学会の論文
- 2003-08-01
著者
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MIYATA Takeshi
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University
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Kim Kwang
Department Of Anatomy Wonkwang University
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Kim K
Department Of Pharmaceutical Sciences University Of Maryland School Of Pharmacy
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Hisatsune Akinori
Department Of Chemico-pharmacological Sciences Graduate School Of Pharmaceutical Sciences Kumamoto U
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Kim Do
Department Of Applied Mathematics Pukyong National University
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Miyata Takeshi
Department Of Chemico-pharmacological Sciences Graduate School Of Pharmaceutical Sciences Kumamoto U
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Miyata Takeshi
Department Of Pharmacological Sciences Faculty Of Pharmaceutical Sciences Kumamoto University
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Kim Do
Department Of Pharmaceutical Sciences University Of Maryland School Of Pharmacy
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Kim Do
Department Of Applied Mathematics College Of Natural Sciences National Fisheries University Of Pusan
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KIM Kwang
Department of Advanced Materials Engineering (Polymerics Program), Korea Advanced Institute of Science and Technology (KAIST)
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