Calcineurin Contributes to the Enhancing Effect of Adenosine on Nerve Growth Factor-Induced Neurite Outgrowth via the Decreased Duration of p38 Mitogen-Activated Protein Kinase Phosphorylation
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概要
- 論文の詳細を見る
Adenosine enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. We found that adenosine increases NGF-induced phosphorylation of extracellular signal-regulated kinase (ERK), but decreases the duration of phosphorylation of p38 mitogen-activated protein (MAP) kinase. Therefore, we further examined the involvement of protein phosphatase in these effects of adenosine. FK506, a specific calcineurin inhibitor, inhibited the enhancing effect of adenosine on the NGF-induced neurite outgrowth and increased the duration of p38 MAP kinase phosphorylation without affecting ERK phosphorylation. These results suggest that adenosine decreases the duration of p38 MAP kinase via calcineurin activation, which contributes to the enhancement of NGF-induced neurite outgrowth.
- 社団法人 日本薬理学会の論文
- 2004-05-20
著者
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Hori Masatoshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University
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ISHII Toshiaki
Department of Molecular Physiology and Biochemistry, Research Institute for Advanced Science and Tec
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Hori Masatoshi
Department Of Radiology Graduate School Of Medicine Osaka University
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Ishii Toshiaki
Department Of Cardiology Surugadai-nihon University Hospital
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Ishii Toshiaki
Department Of Pathobiological Science Obihiro University Of Agriculture And Veterinary Medicine
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NISHIMURA Masakazu
Department of Pathobiological Science, Obihiro University of Agriculture and Veterinary Medicine
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Muroi Yoshikage
Department of Pathogenetic Veterinary Science, The United Graduate School of Veterinary Sciences, Gi
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Muroi Yoshikage
Dep. Of Basic Veterinary Medicine Obihiro Univ. Of Agriculture And Veterinary Medicine
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Muroi Yoshikage
Department Of Pathogenetic Veterinary Science The United Graduate School Of Veterinary Sciences Gifu
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TERAMOTO Kentarou
Department of Pathobiological Science, Obihiro University of Agriculture and Veterinary Medicine
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Nishimura Masakazu
Department Of Pathobiological Science Obihiro University Of Agriculture And Veterinary Medicine
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Teramoto Kentarou
Department Of Pathobiological Science Obihiro University Of Agriculture And Veterinary Medicine
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Hori Masatoshi
Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences The Universit
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Muroi Yoshikage
Department of Pathobiological Science, Obihiro University of Agriculture and Veterinary Medicine
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