Species differences in inhibitory effect of Li+ on high K+-induced contraction in the lleal longitudinal smooth muscle.
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概要
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The effects of Li<SUP>+</SUP> substitution for external Na<SUP>+</SUP> in the medium on a 60 mM KCl (60K<SUP>+</SUP>)-induced contraction were compared in the ileal longitudinal smooth muscles isolated from monkey, rabbit, guinea pig and rat. Li<SUP>+</SUP> substitution inhibited the 60K<SUP>+</SUP>-induced contraction in the ileum of all the animal species. Greater inhibitory effect was observed with the increase in external Li<SUP>+</SUP> concentration and the increase in incubation period with Li<SUP>+</SUP>. Intracellular Li<SUP>+</SUP> contents of these muscles also increased with the increase in external Li<SUP>+</SUP> concentration and the incubation period. Thus, a good correlation was obtained between Li<SUP>+</SUP>-induced inhibition of 60K<SUP>+</SUP>-induced contraction and the increase in Li<SUP>+</SUP> content. However, close examination revealed that the contraction in monkey and rat ileum was inhibited by much lower Li<SUP>+</SUP> accumulation than that in guinea pig and rabbit ileum, suggesting the existence of species difference in the sensitivity of the ileal smooth muscle to the inhibitory effect of Li<SUP>+</SUP> substitution, and a mechanism for the species differences in the inhibitory action of Li<SUP>+</SUP>-substitution was discussed.
- 公益社団法人 日本薬理学会の論文
著者
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Hori Masatoshi
Department Of Radiology Graduate School Of Medicine Osaka University
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Shimizu Kazumasa
Department Of Medicine Monash Medical Centre
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URAKAWA Norimoto
Department of Veterinaly Pharmacology, Faculty of Agriculture, University of Tokyo
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NAKAYA Michiaki
Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical College
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NAKAJYO Shinjiro
Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical Colleg
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NODA Kazue
Department of Veterinary Pharmacology, Nippon Veterinary and Zootechnical College
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