THE INHIBITORY EFFECT OF PAPAVERINE ON RESPIRATION-DEPENDENT CONTRACTURE OF GUINEA PIG TAENIA COLI IN HIGH-K MEDIUM. I. THE RELATIONSHIP BETWEEN CONTRACTURE AND RESPIRATION
スポンサーリンク
概要
- 論文の詳細を見る
Papaverine (Pap) inhibited a tonic tension development in guinea pig taenia coli induced by an elevation of the potassium concentration of the medium to 40 mM (40-K). The ID50 of Pap was 4.5 × 10<SUP>-6</SUP> M. Inhibition of the 40-K induced tonic tension by Pap was dependent on the calculated concentration of non-ionized form, but not the ionized form. Inhibition of the tonic tension by Pap and various metabolic inhibitors was not antagonized by raising the Ca<SUP>++</SUP> concentration in the medium. Results obtained from simultaneous measurement of the 40-K induced O<SUB>2</SUB> consumption and tension illustrated that the inhibition of O<SUB>2</SUB> consumption rapidly induced the inhibition of the tension. Furthermore, glucose removal, amytal or Pap resulted in a progressive relationship between the inhibition of O<SUB>2</SUB> consumption and the inhibition of tension. The inhibition of Pap as determined by O<SUB>2</SUB> consumption was not reversed by application of 10<SUP>-4</SUP> M 2, 4-dinitrophenol (DNP). These results plus graphical analysis of the mechanical response suggest that Pap may penetrate the cell membrane and inhibit mitochondrial respiration, thereby inhibiting this very respiration-dependent contracture.
- 社団法人 日本薬理学会の論文
著者
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Tsuda Shuji
Department Of Applied Veterinary Science The Doctoral Course Of The United Graduate School Of Veteri
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URAKAWA Norimoto
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
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TSUDA Shoji
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
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SAITO Yukio
Medical Laboratory of Pharmacology, Central Research Laboratories, Sankyo Co., Ltd.
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SAITO Yukio
Medical Laboratory for Pharmacology, Central Research Laboratories, Sankyo Co. Ltd.
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URAKAWA Norimoto
Department of Veterinaly Pharmacology, Faculty of Agriculture, University of Tokyo
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