Contractile effects of jellyfish toxin extracted from Carybdea rastonii on isolated rabbit aorta.
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概要
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Effects of the toxic component of jellyfish (<I>Carybdea rastonii</I>) (pCrTX) on the smooth muscle tension of isolated rabbit thoracic aorta were examined. pCrTX, at concentrations higher than 10<SUP>-7</SUP> g/ml, caused slowly developing tension that reached its maximum after about 1 hr. This contraction was partially inhibited by pretreatment of the tissue with phentolamine (5×10<SUP>-6</SUP> M) or indomethacin (10<SUP>-5</SUP> M). The contraction induced by pCrTX was partially inhibited by nicardipine (10<SUP>-7</SUP> M) and markedly augmented by Bay k8644 (10<SUP>-6</SUP> M). In low-Na<SUP>+</SUP> solution, the rate of rise of the pCrTX-induced contraction was significantly reduced. Removal of external Ca<SUP>2+</SUP> -inhibited the pCrTX-induced contraction by about 30%, while chlorpromazine, trifluoperazine, prenylamine and papaverine (10<SUP>-4</SUP> M) completely inhibited the contraction. pCrTX itself did not cause any contraction in saponinskinned smooth muscle and had no effect on the Ca<SUP>2+</SUP>-induced contractile tension. It has been reported that pCrTX-induced contraction is attributable to the release of endogenous catecholamines and also to the increase in Ca<SUP>2+</SUP> influx in smooth muscle (Azuma et al., 1986). The present results confirmed the previous suggestion and further suggested that a portion of the contraction is due to release of prostaglandin(s) and also to the direct effect on smooth muscle which is not dependent on Ca<SUP>2+</SUP> influx.
- 公益社団法人 日本薬理学会の論文
著者
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Azuma Hiroshi
Department Of Biosystem Regulation Institute Of Biomaterials And Bioengineering
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Nakajima Terumi
Department Of Analytical Chemistry Faculty Of Pharmaceutical Science The University Of Tokyo
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Ozaki Hiroshi
Department Of Electronic Engineering Faculty Of Engineering Osaka University
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NAGASE Hiromi
Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
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URAKAWA Norimoto
Department of Veterinaly Pharmacology, Faculty of Agriculture, University of Tokyo
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Karaki Hideaki
Department of Veterinary Medical Sciences, Faculty of Agriculture, The University of Tokyo
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URAKAWA Norimoto
Department of Veterinary Pharmacology, Faculty of Agriculture, The University of Tokyo
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KARAKI Hideaki
Department of Veterinary Pharmacology, Faculty of Agriculture, The University of Tokyo
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NAKAJIMA Terumi
Department of Analytical Chemistry of Pharmaceutical Science, The University of Tokyo
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NAGASE Hiromi
Department of Veterinary Pharmacology, Faculty of Agriculture, The University of Tokyo
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