Ca^<2+>-Sensitization of Contraction in the h1 Calponin-Deficient Smooth Muscle

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概要

• 論文の詳細を見る

• Role of h1 calponin on Ca2+-sensitivity of smooth muscle contraction was investigated using h1 calponin gene-deficient mice (CP−/−) and wild type mice (CP+/+). PGF2α induced a comparable force in intact aorta of CP+/+ and CP−/−. DPB showed similar effects to PGF2α. In membrane-permeabilized ileal smooth muscle, PDBu enhanced Ca2+-sensitivity of contraction comparably in CP+/+ and CP−/−. GTPγ-S showed similar effects. Our results suggest that h1 calponin does not regulate Ca2+-sensitivity in the contractile mechanism of smooth muscle.

• 社団法人 日本薬理学会の論文
• 2000-12-01

著者

• Hori Masatoshi

  Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University

• Ozaki Hiroshi

  Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University

• Hori Masatoshi

  Department Of Radiology Graduate School Of Medicine Osaka University

• Hori M

  Leaf Tobacco Research Center Japan Tobacco Inc.:(present Address)laboratory Of Insect Science And Bi

• Tasaki Katsunari

  Department Of Hygiene & Preventive Medicine School Of Medicine Yamagata University

• KARAKI Hideaki

  Department of Veterinary Pharmacology, Graduate School of Agricultural and Life Sciences, The Univer

• Ozaki H

  Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences University Of

• Ozaki Hiroshi

  Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences The Universit

• KATSUKI Motoya

  Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University

• YOSHIMOTO Ryo

  Department of Veterinaty Pharmacology, Graduate School of Agriculture and Life Sciences, The Univers

• TAKAHASHI Katsuhito

  Department of Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases

• TANIGUCHI Shun-ichiro

  Research Center on Aging and Adaptation, Shinshu University School of Medicine

• Kobayashi Haruo

  Department Of Veterinary Medicine Faculty Of Agriculture Iwate University

• Hori M

  Division Of Veterinary Pharmacology Nippon Veterinary And Animal Science University

• Yoshimoto R

  Univ. Tokyo Tokyo Jpn

• Yoshimoto Ryo

  Department Of Pharmacology Graduate School Of Agriculture And Life Sciences The University Of Tokyo

• Katsuki Motoya

  Department Of Dna Biology School Of Medicine Tokai University:central Institute For Experimental Ani

• Karaki Hideaki

  Department Of Veterinary Medicine Faculty Of Agriculture Iwate University

• Hori Masatoshi

  Division Of Veterinary Pharmacology Nippon Veterinary And Animal Science University

• Taniguchi Shun-ichiro

  Research Center On Aging And Adaptation Shinshu University School Of Medicine

• Takahashi Katsuhito

  Department Of Medicine Molecular Biology Unit Osaka Medical Center For Cancer And Cardiovascular Dis

• Katsuki Motoya

  Department Of Dna Biology And Embryo Engineering Institute For Medical Science The University Of Tok

• Katsuki Motoya

  Department Of Dna Biol. Embryo Engeneering Institute Of Medical Science University Of Tokyo

• Karaki Hideaki

  Department Of Veterinary Pharmacology Graduate School Of Agricultural And Life Sciences The Universi

• Ozaki Hiroshi

  Department Of Electronic Engineering Faculty Of Engineering Osaka University

• Ozaki Hiroshi

  Department Of Veterinary Pharmacology Graduate School Of Agriculture And Life Sciences The Universit

• Karaki Hideaki

  Department of Veterinary Medical Sciences, Faculty of Agriculture, The University of Tokyo

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