The Influence of Chronic Sympathectomy on Cutaneous Blood Flow in the Rat Tail
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概要
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Tail blood flow (TBF) in the rat markedly increases during sympathetic withdrawal such as hyperthermia or lumbar sympathetic blockade. However, a long-term alteration of TBF after chronic sympathetic denervation is not well understood. In the present study, TBF following lumbar sympathectomy (LSX) was observed to ascertain whether subsequent changes in TBF occur in the absence of the sympathetic nervous activity in the rat tail. Assessed by recording tail and rectal temperature, the LSX immediately caused an increase in TBF. TBF was gradually decreased along with time and returned to the sham operated (SO) control level within 4 days. About a week after the surgery, a rapid increase in TBF in response to whole body heating was almost abolished in denervated animals. Neither hexamethonium (20 mg/kg, i.v.) for ganglion blockade nor intra-arterial infusion of α-receptor antagonist, phentolamine (10, 100 μg) produced vasodilation in LSX animals. Nitroprusside, a donor of nitric oxide, produced an increase in TBF in both LSX and SO animals. These results indicate that the tail vasculature after LSX constricts with capability to be vasodilated independent of sympathetic reinnervation. Quantification of the tail vascular mRNA expression by reverse transcriptase-polymerase chain reaction showed less endothelial nitric oxide synthetase in LSX group than that in SO group whereas endothelin-1 was not significantly different in both groups. It is suggested that functional changes in tail vascular endothelium takes at least a part in the reduction in TBF after LSX.
著者
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Hori Masatoshi
Department Of Radiology Graduate School Of Medicine Osaka University
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YANAGIYA Yusuke
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute
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Kuwahara Masayoshi
Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Science The Unive
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Tsubone Hirokazu
Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Science The Unive
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Yoshimura Ryoichi
Department Of Applied Biology Kyoto Institute Of Technology
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SUGANO Shigeru
Department of Comparative Pathophysiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo
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KUWAHARA Masayoshi
Department of Comparative Pathophysiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
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YANAGIYA Yusuke
Department of Comparative Pathophysiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
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TSUBONE Hirokazu
Department Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
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YOSHIMURA Ryoichi
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan
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HORI Masatoshi
Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
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