Antihypertensive Effects of Peptides in Autolysate of Bonito Bowels on Spontaneously Hypertensive Rats

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概要

• 論文の詳細を見る

• An autolysate of bonito bowels was treated with ultrafiltration, loose RO concentration, ion-exchange chromatography, and reverse phase chromatography to increase its potency to inhibit angiotensin I-converting enzyme (ACE) activity by 16-fold. Oral administration of the partially purified autolysate decreased the systolic blood pressure of spontaneously hypertensive rats (SHR) in a dose-dependent manner at the doses of 1 g peptides/kg or higher. The relationship between the antihypertensive activity (in vivo) of the partially purified preparation and its ACE inhibitory activity (in vitro) in comparison with previously reported ACE inhibitory peptides is discussed.

• 社団法人日本農芸化学会の論文
• 1993-12-23

著者

• KUWAHARA Masayoshi

  Department of Comparative Pathophysiology, Granduate School of Agricultural and Life Sciences, The U

• Fujii Mikio

  Foods Research Group Foods Division Asahi Chemical Industry Co. Ltd.

• KARAKI Hideaki

  Department of Veterinary Pharmacology, Graduate School of Agricultural and Life Sciences, The Univer

• SUGANO Shigeru

  Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Med

• Shimizu Takahiko

  Department Of Applied Biochemistry Faculty Of Applied Biological Sciences Hiroshima University

• Kuwahara M

  Univ. Tokyo Tokyo Jpn

• Kuwahara Masayoshi

  Department Of Comparative Pathophysiology Graduate School Of Agricultural And Life Science The Unive

• Matsumura Nobuyasu

  Foods Research Group, Foods Division, Asahi Chemical Industry Co., Ltd.

• Mito Kazue

  Foods Research Group, Foods Division, Asahi Chemical Industry Co., Ltd.

• Shimizu Toshio

  Foods Research Group, Foods Division, Asahi Chemical Industry Co., Ltd.

• Fujii Michihiko

  Kihara Inst. For Biological Res. And Graduate School Of Integrated Sci. Yokohama City Univ.

• Fujii Michihiko

  Kihara Institute For Biological Research And Graduate School Of Integrated Science Yokohama City Uni

• Mito Kazue

  Foods Research Group Foods Division Asahi Chemical Industry Co. Ltd.

• Sugano Shigeru

  Department Of Geriatric And Environmental Dermatology Nagoya City University Graduate School Of Medi

• Sugano Shigeru

  Department Of Veterinary Medical Sciences Faculty Of Agriculture The University Of Tokyo

• Karaki H

  Univ. Tokyo Tokyo Jpn

• Shimizu T

  Tanabe Seiyaku Co. Ltd. Osaka Jpn

• Matsumura N

  Yokohama City Univ. Yokohama Jpn

• Karaki Hideaki

  Department Of Veterinary Medicine Faculty Of Agriculture Iwate University

• Fujii Mitsuko

  Division Of Bioscience Graduate School Of Natural Science And Technology Okayama University

• Shimizu Toshio

  Foods Research Group Asahi Chemical Industry Co. Ltd.

• Karaki Hideaki

  Department of Veterinary Medical Sciences, Faculty of Agriculture, The University of Tokyo

• SUGANO Shigeru

  Department of Comparative Pathophysiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo

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