Suppression of Senescence in Normal Human Fibroblasts by Introduction of Dominant-Negative p53 Mutants or Human Papilloma Virus Type 16 E6 Protein
スポンサーリンク
概要
- 論文の詳細を見る
Transfection of nearly senesced human fibroblasts with plasmids encoding HPV16 E6 protein or dominant-negative p53 mutants greatly increased their colony-forming ability. Isolated colonies with these plasmids showed extension of lifespan compared to those with a control plasmid. These data demonstrate that p53 plays a major role in senescence in normal human fibroblasts.
- 社団法人日本農芸化学会の論文
- 1998-07-23
著者
-
Fujii Mikio
Foods Research Group Foods Division Asahi Chemical Industry Co. Ltd.
-
FUJII Michihiko
Division of Biochemistry, Kihara Institute for Biological Research and Graduate School of Integrated
-
AYUSAWA Dai
Division of Biochemistry, Kihara Institute for Biological Research and Graduate School of Integrated
-
Ayusawa D
Kihara Inst. For Biological Res. And Graduate School Of Integrated Sci. Yokohama City Univ.
-
Ayusawa D
Division Of Biochemisty Kihara Institute For Biological Research Yokohama City University
-
Ayusawa Dai
Kihara Institute For Biological Research And Graduate School Of Integrated Science Yokohama City Uni
-
Ayusawa Dai
Division Of Biochemistry Kihara Institute For Biological Research And Graduate School Of Integrated
-
Fujii Michihiko
Kihara Inst. For Biological Res. And Graduate School Of Integrated Sci. Yokohama City Univ.
-
Fujii Michihiko
Kihara Institute For Biological Research And Graduate School Of Integrated Science Yokohama City Uni
-
Nakabayashi Kazuhiko
Kihara Institute For Biological Research Yokohama City University
-
Nakabayashi Kazuhiko
Division Of Biochemisty Kihara Institute For Biological Research Yokohama City University
-
Ayusawa Dai
Kihara Inst. For Biological Res. And Graduate School Of Integrated Sci. Yokohama City Univ.
-
Ide A
Kihara Institute For Biological Research Yokohama City University
-
IDE Akiko
Division of Biochemistry, Kihara Institute for Biological Research and Graduate School of Integrated
-
NAKABABASHI Kazuhiko
Division of Biochemistry, Kihara Institute for Biological Research and Graduate School of Integrated
-
Fujii Mitsuko
Division Of Bioscience Graduate School Of Natural Science And Technology Okayama University
-
Ayusawa Dai
Kihara Institute For Biological Research And Graduate School Of Integrated Science Yokohama City Uni
関連論文
- Volatilization of Mercury by an Iron Oxidation Enzyme System in a Highly Mercury-resistant Acidithiobacillus ferrooxidans Strain MON-1(Microbiology & Fermentation Technology)
- Antihypertensive Effects of Peptides in Autolysate of Bonito Bowels on Spontaneously Hypertensive Rats
- Uncoupling of Longevity and Paraquat Resistance in Mutants of the Nematode Caenorhabditis elegans
- Purification and Characterization of β-N-Acetylhexosaminidase from the Liver of a Prawn, Penaeus japonicus
- Kinetics of a Chitinase from a Prawn, Penaeus japonicus(Biological Chemistry)
- Novel Aminopeptidase Specific for Glycine from Actinomucor elegans(Biochemistry & Molecular Biology)
- The Human MYOD1 Transgene Is Suppressed by 5-Bromodeoxyuridine in Mouse Myoblasts
- 5-Halogenated Thymidine Analogues Induce a Senescence-like Phenomenon in HeLa Cells(Biochemistry & Molecular Biology)
- 5-Bromodeoxyuridine Induces Senescence-Like Phenomena in Mammalian Cells Regardless of Cell Type or Species
- Dephosphorylation of Specific Proteins during Induction of Senescence in Immortal human Fibroblasts Expressing Thermolabile SV40 T Antigen
- The Introduction of Dominant-Negative p53 Mutants Suppresses Temperature Shift-Induced Senescence in Immortal Human Fibroblasts Expressing a Thermolabile SV40 Large T Antigen
- Isolation and Characterization of Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Bonito Bowels
- Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Bonito Bowels Autolysate
- Human UDP-Galactose Translocator: Molecular Cloning of a Complementary DNA That Complements the Genetic Defect of a Mutant Cell Line Deficient in UDP-Galactose Translocator
- Nuclear Swelling Occurs during Premature Senescence Mediated by MAP Kinases in Normal Human Fibroblasts
- 5-Bromo-2'-deoxyuridine Efficiently Suppresses Division Potential of the Yeast Saccharomyces cerevisiae(Biochemistry & Molecular Biology)
- Cloning of the pepX Gene of Lactobacillus helveticus IFO3809 Encoding Salt-Tolerant X-Prolyl Dipeptidyl Aminopeptidase and Characterization of the Enzyme
- Proteasome Inhibitors Induce Changes in Chromatin Structure Characteristic of Senescent Human Fibroblasts
- Identification of the UV-Responsive Sequence in the Human Tissue Plasminogen Activator Gene
- Inhibition of the Acid Lipase Activity by Apolipoprotein A-I in the Presence of Lysosomal Proteases
- Suppression of Senescence in Normal Human Fibroblasts by Introduction of Dominant-Negative p53 Mutants or Human Papilloma Virus Type 16 E6 Protein
- Acid Lipase Inhibitor in Chicken Plasma Identified as Apolipoprotein A-I
- An Algorithm for Solving Linear Ordinary Differential Equations of Fuchsian Type with Three Singular Points
- Defective DNA Replication and Repair Associated with Decreases in Deoxyribonucleotide Pools in a Mouse Cell Mutant With Thermolabile Ubiquitin-Activating Enzyme E11
- Complementation by a Cloned Human Ubiquitin-Activating Enzyme E1 of the S-Phase-Arrested Mouse FM3A Cell Mutant with Thermolabile E1
- 5-Bromodeoxyuridine Increases Transient Expression of Ectopic Genes in Human Cells
- Effects of Truss Mattress upon Sleep and Bed Climate
- Nuclear Swelling Occurs during Premature Senescence Mediated by MAP Kinases in Normal Human Fibroblasts
- Reduction of Hg^ with Reduced Mammalian Cytochrome c by Cytochrome c Oxidase Purified from a Mercury-Resistant Acidithiobacillus ferrooxidans Strain, MON-1
- 5-Bromodeoxyuridine Increases Transient Expression of Ectopic Genes in Human Cells
- Induction Patterns of Chitinases in Yam Callus by Inoculation with Autoclaved Fusarium oxysporum, Ethylene, and Chitin and Chitosan Oligosaccharides
- Efficiency of Chitinolytic Enzymes in the Formation of Tricholoma matsutake Protoplasts(Biological Chemistry)
- INTERACTION OF ACYLATED PROTEIN WITH BIOLOGICAL MEMBRANE
- Correlation between Membrane Binding and Phosphorylation by Protein Kinase C of Acylated Protein(Biological Chemistry)
- Kinetics of Chitinase from Yam, Dioscorea opposita THUNB(Biological Chemistry)
- Callus Induction from Yam, Dioscorea opposita Thunb., and The Subculture(Biological Chemistry)
- Sublethal Doses of Surfactants Induce Premature Senescence in Normal Human Skin Cells
- The Introduction of Dominant-Negative p53 Mutants Suppresses Temperature Shift-Induced Senescence in Immortal Human Fibroblasts Expressing a Thermolabile SV40 Large T Antigen.