Proteasome Inhibitors Induce Changes in Chromatin Structure Characteristic of Senescent Human Fibroblasts
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概要
- 論文の詳細を見る
Inhibitors of proteasome induced premature senescence in normal human fibroblasts. Besides morphological alteration and expression of senescence marker genes, these cells manifested senescence-associated heterochromatic foci under staining of the nuclei with DAPI similar to normally senescent cells. These results suggest that declining ability in protein degradation may be involved in the formation of heterochromatic foci in senescent fibroblasts.
- 社団法人 日本農芸化学会の論文
- 2004-11-23
著者
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Mizutani Emi
Kihara Institute For Biological Research And Graduate School Of Integrated Science Yokohama City Uni
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Ayusawa D
Kihara Inst. For Biological Res. And Graduate School Of Integrated Sci. Yokohama City Univ.
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Ayusawa D
Division Of Biochemisty Kihara Institute For Biological Research Yokohama City University
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Ayusawa Dai
Kihara Institute For Biological Research And Graduate School Of Integrated Science Yokohama City Uni
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Ayusawa Dai
Division Of Biochemistry Kihara Institute For Biological Research And Graduate School Of Integrated
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Fujii Michihiko
Kihara Inst. For Biological Res. And Graduate School Of Integrated Sci. Yokohama City Univ.
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Fujii Michihiko
Kihara Institute For Biological Research And Graduate School Of Integrated Science Yokohama City Uni
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Ayusawa Dai
Kihara Inst. For Biological Res. And Graduate School Of Integrated Sci. Yokohama City Univ.
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UKEKAWA Ryo
Kihara Institute for Biological Research and Graduate School of Integrated Science, Yokohama City Un
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MAEGAWA Naoyuki
Kihara Institute for Biological Research and Graduate School of Integrated Science, Yokohama City Un
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Ukekawa Ryo
Kihara Institute For Biological Research And Graduate School Of Integrated Science Yokohama City Uni
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Fujii Mitsuko
Division Of Bioscience Graduate School Of Natural Science And Technology Okayama University
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Maegawa Naoyuki
Kihara Institute For Biological Research And Graduate School Of Integrated Science Yokohama City Uni
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Ayusawa Dai
Kihara Institute For Biological Research And Graduate School Of Integrated Science Yokohama City Uni
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UKEKAWA Ryo
Department of Genome System Science, Yokohama City University
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Ukekawa Ryo
Department Of Genome System Science Yokohama City University
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