Isolation and Characterization of Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Bonito Bowels
スポンサーリンク
概要
- 論文の詳細を見る
Four angiotensin I-converting enzyme (EC 3.4.15.1) (ACE) inhibitory peptides C105, C107, C111, and C112 were isolated from bonito bowels. C111 was obtained from liver, while the others were from intestine. Their amino acids were sequenced as Ser-Val-Ala-Lys-Leu-Glu-Lys for C105, Ala-Leu-Pro-His-Ala for C107, Gly-Val-Tyr-Pro-His-Lys for C111, and Ile-Arg-Pro-Val-Gln for C112. Their ACE inhibition activities were measured for synthetic peptides. The IC_<50> of these peptides were estimated to be 82, 79, 1.6, and 1.4μM, respectively. Carboxyl-terminal amino acid(s) were considered to be essential for their expression of ACE inhibition for C105, C107, and C111, while the amino terminal tripeptide Ile-Arg-Pro of C112 was presumed to inhibit ACE after the removal of a dipeptide from C112 with ACE digestion. Presumed original proteins of these peptides are discussed.
- 社団法人日本農芸化学会の論文
- 1993-10-23
著者
-
Fujii Mikio
Foods Research Group Foods Division Asahi Chemical Industry Co. Ltd.
-
Shimizu Takahiko
Department Of Applied Biochemistry Faculty Of Applied Biological Sciences Hiroshima University
-
Matsumura Nobuyasu
Foods Research Group, Foods Division, Asahi Chemical Industry Co., Ltd.
-
Shimizu Toshio
Foods Research Group, Foods Division, Asahi Chemical Industry Co., Ltd.
-
Fujii Michihiko
Kihara Inst. For Biological Res. And Graduate School Of Integrated Sci. Yokohama City Univ.
-
Fujii Michihiko
Kihara Institute For Biological Research And Graduate School Of Integrated Science Yokohama City Uni
-
Takeda Yasuhiro
Department Of Animal Science Utsunomiya University
-
Shimizu T
Tanabe Seiyaku Co. Ltd. Osaka Jpn
-
Takeda Yasuhiko
Foods Research Group, Foods Division, Asahi Chemical Industry Co., Ltd.
-
Matsumura N
Yokohama City Univ. Yokohama Jpn
-
Takeda Yasuhiko
Foods Research Group Asahi Chemical Industry Co. Ltd.
-
Fujii Mitsuko
Division Of Bioscience Graduate School Of Natural Science And Technology Okayama University
-
Shimizu Toshio
Foods Research Group Asahi Chemical Industry Co. Ltd.
関連論文
- Volatilization of Mercury by an Iron Oxidation Enzyme System in a Highly Mercury-resistant Acidithiobacillus ferrooxidans Strain MON-1(Microbiology & Fermentation Technology)
- Studies on Somnolence in the Daytime Caused by Drugs Used for Neuropathic Pain
- Major Isoforms of Starch Branching Enzymes in Premature Seeds of Kidney Bean (Phaseolus vulgaris L.)
- Antihypertensive Effects of Peptides in Autolysate of Bonito Bowels on Spontaneously Hypertensive Rats
- Interaction of Starfish Embryonic Cells with the Complex of Okadaic Acid and Monoclonal Antibody Specific to Okadaic Acid
- Effects of Okadaic Acid on Embryonic Development of the Starfish Asterina pectinifera
- Uncoupling of Longevity and Paraquat Resistance in Mutants of the Nematode Caenorhabditis elegans
- Hypnotic and Sleep Quality-Enhancing Properties of Kavain in Sleep-Disturbed Rats
- Novel Aminopeptidase Specific for Glycine from Actinomucor elegans(Biochemistry & Molecular Biology)
- The Human MYOD1 Transgene Is Suppressed by 5-Bromodeoxyuridine in Mouse Myoblasts
- 5-Halogenated Thymidine Analogues Induce a Senescence-like Phenomenon in HeLa Cells(Biochemistry & Molecular Biology)
- 5-Bromodeoxyuridine Induces Senescence-Like Phenomena in Mammalian Cells Regardless of Cell Type or Species
- Dephosphorylation of Specific Proteins during Induction of Senescence in Immortal human Fibroblasts Expressing Thermolabile SV40 T Antigen
- The Introduction of Dominant-Negative p53 Mutants Suppresses Temperature Shift-Induced Senescence in Immortal Human Fibroblasts Expressing a Thermolabile SV40 Large T Antigen
- The N-terminal region of the starch-branching enzyme from Phaseolus vulgaris L. is essential for optimal catalysis and structural stability
- Isolation and Characterization of Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Bonito Bowels
- Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Bonito Bowels Autolysate
- Effects of Calmodulin and Calmodulin Antagonists on Neutral Ca^-ATPase in the Membrane Fraction of Human Milk
- Enzymatic Properties of Two Calcium-stimulated ATPases in the Neutral and Acidic pH Regions Found in the Membrane Fraction of Human Milk
- Prediction of Mixing Pattern by Using Power Number Diagram in Baffled and Unbaffled Mixing Vessels
- Nuclear Swelling Occurs during Premature Senescence Mediated by MAP Kinases in Normal Human Fibroblasts
- Expression of Cytochrome c-553(CO) Gene That Complements the Second Subunit Deficitncy of Membrane-Bound Alcohol Dehydrogenase in Gluconobacter suboxydans subsp. α
- Comparison of the Second Alcohol Dehydrogenase Subunit Gene in Acetic Acid Bacteria
- Cloning and Sequencing of the Gene Encoding Cytochrome c-553 (CO) from Gluconobacter suboxydans
- 5-Bromo-2'-deoxyuridine Efficiently Suppresses Division Potential of the Yeast Saccharomyces cerevisiae(Biochemistry & Molecular Biology)
- Cloning of the pepX Gene of Lactobacillus helveticus IFO3809 Encoding Salt-Tolerant X-Prolyl Dipeptidyl Aminopeptidase and Characterization of the Enzyme
- Proteasome Inhibitors Induce Changes in Chromatin Structure Characteristic of Senescent Human Fibroblasts
- Role of Cytochrome c-553(CO), the Second Subunit of Alcohol Dehydrogenase, in the Azide-Insensitive Respiratory Chain and in Oxidative Fermentation of Gluconobacter Species
- Identification of the UV-Responsive Sequence in the Human Tissue Plasminogen Activator Gene
- Inhibition of the Acid Lipase Activity by Apolipoprotein A-I in the Presence of Lysosomal Proteases
- Suppression of Senescence in Normal Human Fibroblasts by Introduction of Dominant-Negative p53 Mutants or Human Papilloma Virus Type 16 E6 Protein
- Acid Lipase Inhibitor in Chicken Plasma Identified as Apolipoprotein A-I
- 5-Bromodeoxyuridine Increases Transient Expression of Ectopic Genes in Human Cells
- Effect of Valerian Extract Preparation (BIM) on the Sleep-Wake Cycle in Rats(Pharmacology)
- Nuclear Swelling Occurs during Premature Senescence Mediated by MAP Kinases in Normal Human Fibroblasts
- Correlation of Power Consumption for Propeller and Pfaudler Type Impellers
- Reduction of Hg^ with Reduced Mammalian Cytochrome c by Cytochrome c Oxidase Purified from a Mercury-Resistant Acidithiobacillus ferrooxidans Strain, MON-1
- 5-Bromodeoxyuridine Increases Transient Expression of Ectopic Genes in Human Cells
- Changes of Sleep Patterns in Rats with Chronic Constriction Injury under Aversive Conditions(Pharmacology)
- Effects of Some H_1-Antagonists on the Sleep-Wake Cycle in Sleep-Disturbed Rats
- Sublethal Doses of Surfactants Induce Premature Senescence in Normal Human Skin Cells
- Rescue Therapy with Tacrolimus for a Patient with Severe Ulcerative Colitis Refractory to Combination Leukocytapheresis and High-Dose Corticosteroid Therapy
- The Introduction of Dominant-Negative p53 Mutants Suppresses Temperature Shift-Induced Senescence in Immortal Human Fibroblasts Expressing a Thermolabile SV40 Large T Antigen.