Rescue Therapy with Tacrolimus for a Patient with Severe Ulcerative Colitis Refractory to Combination Leukocytapheresis and High-Dose Corticosteroid Therapy
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概要
- 論文の詳細を見る
A19-year-old man complaining of severe diarrhea and hematochezia was admitted to our hospital. Endoscopic findings and laboratory data revealed that he had ulcerative colitis (UC). Despite combination therapy with high-dose corticosteroids and intensive granulocytapheresis, his condition did not improve. Therefore, we initiated tacrolimus therapy. Intravenous administration of tacrolimus with a trough level of 10 to 15 ng/ml relieved his abdominal symptoms within 1 week. The patient experienced no UC relapse 1 year after treatment with oral tacrolimus. Tacrolimus is a promising therapy for patients with UC refractory to the combination of high-dose corticosteroids and leukocytapheresis.
- 社団法人 日本内科学会の論文
著者
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Uza Norimitsu
Department Of Gastroenterology & Hepatology Graduate School Of Medicine Kyoto University
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Inoue Satoko
Department Of Gastroenterology & Hepatology Graduate School Of Medicine Kyoto University
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Yoshino Takuya
Department of Cardiology, Jikei University Aoto Hospital
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MATSUURA MINORU
Department of Endoscopic Medicine and Gastroenterology, Kyoto University Hospital
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Chiba Tsutomu
Deparment Of Gastroenterology And Hepatology Kyoto University Graduate School Of Medicine
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MIKAMI SAKAE
Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
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KASAHARA KATSUHIRO
Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
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Nakase Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University
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Takeda Yasuhiro
Department Of Animal Science Utsunomiya University
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Ueno Satoru
Department Of Biochemistry Faculty Of Veterinary Medicine Hokkaido University
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Kitamura Hiroshi
Department Of Applied Chemistry
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Takeda Yasuhiro
Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
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Yoshino Takuya
Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
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