Acute Cerebral Infarction during Combination Chemotherapy with S-1 and Cisplatin for a Young Patient with a Mucin-Producing Adenocarcinoma of the Stomach
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概要
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We report a 29-year-old woman with gastric cancer who developed Trousseau's syndrome, a malignancy-related thromboembolism, during chemotherapy. She was diagnosed with a mucin-producing adenocarcinoma of the stomach, and chemotherapy with S-1 and cisplatin was commenced. During treatment, she developed a sudden onset of right hemiplegia. Magnetic resonance imaging showed an acute cerebral infarction of the left cerebral hemisphere. The underlying pathophysiology is thought to be chronic disseminated intravascular coagulation due to mucin-producing adenocarcinomas. However, cisplatin-induced vascular toxicity and hypercoagulability caused by decreased plasma protein C activity, elevated plasma von-Willebrand factor levels, and hypomagnesemia has also been proposed to be associated with thrombogenicity.
- 社団法人 日本内科学会の論文
著者
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Fukui Toshiro
Department Of Gastroenterology And Hepatology Kansai Medical University
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NISHIO Akiyoshi
Department of Gastroenterology and Hepatology, Kansai Medical University
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Chiba Tsutomu
Deparment Of Gastroenterology And Hepatology Kyoto University Graduate School Of Medicine
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Ohashi Shinya
Department Of Gastroenterology And Hepatology Graduate School Of Medicine Kyoto University
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Asada Masanori
Deparment Of Food Science And Technology Faculty Of Agriculture Kyoto University
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Yazumi Shujiro
Department Of Gastroenterology And Hepatology Graduate School Of Medicine Kyoto University
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YAZUMI Shujiro
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University
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Ohashi Shinya
Department of Gastroenterology and Hepatology, Tazuke-Kofukai Medical Research Institute and Kitano Hospital
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Asada Masanori
Department of Gastroenterology and Hepatology, Tazuke-Kofukai Medical Research Institute and Kitano Hospital
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