The Effect of Medical Treatment on Patients with Fistulizing Crohn's Disease: A Retrospective Study
スポンサーリンク
概要
- 論文の詳細を見る
Background Fistulas are a major complication of Crohn's disease (CD), but the treatment strategy for fistulizing Crohn's disease is controversial. The aim of this study is to analyze the efficacy of medical therapy for fistulizing Crohn's disease. Methods Therapeutic regimens and clinical outcome of medical therapy were evaluated in 10 patients with fistulizing Crohn's disease (6 with external fistulas, 4 with internal fistulas). Complete response was defined as fistula closure with complete arrest of drainage in cases of external fistula, and disappearance of the fistula demonstrated by imaging studies in cases of internal fistula. Clinical remission was defined as a Crohn's disease activity index of less than 150 points. Results Complete responses were observed in all 6 patients with external fistulas (4 patients treated with a combination of antibiotics and immunomodulators, and 2 also treated with infliximab). In contrast, fistula closure was observed in only 1 of 4 patients with internal fistulas. Clinical remission of CD was achieved in all patients with external fistulas, whereas there was no significant difference in the CD activity index before and after medical therapy in patients with internal fistulas. Conclusions External fistulas were more responsive to medical therapy than internal fistulas in patients with CD. Combined treatment with antibiotics and immunomodulators might be a suitable initial therapy for CD patients with external fistulas, and infliximab can be used as an additional therapy in cases refractory to this combination therapy. However, randomized controlled studies will be required to investigate what kinds of therapies are optimal for CD patients with fistulas.
- 社団法人 日本内科学会の論文
著者
-
Tamaki Hiroyuki
Department Of Cardiology Mimihara General Hospital
-
Uza Norimitsu
Department Of Gastroenterology & Hepatology Graduate School Of Medicine Kyoto University
-
Inoue Satoko
Department Of Gastroenterology & Hepatology Graduate School Of Medicine Kyoto University
-
MATSUURA MINORU
Department of Endoscopic Medicine and Gastroenterology, Kyoto University Hospital
-
Chiba Tsutomu
Deparment Of Gastroenterology And Hepatology Kyoto University Graduate School Of Medicine
-
MIKAMI SAKAE
Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University
-
Nakase Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University
-
Ueno Satoru
Department Of Biochemistry Faculty Of Veterinary Medicine Hokkaido University
-
Matsuura Minoru
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University
-
Inoue Satoko
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University
-
Mikami Sakae
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University
-
Uza Norimitsu
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University
-
Ueno Satoru
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University
関連論文
- Antibody to hepatitis B core antigen as a screening test for occult hepatitis B virus infection in Egyptian chronic hepatitis C patients
- Efficacy and safety of omeprazole in Japanese patients with nonerosive reflux disease
- Gastroesophageal acid reflux in elderly patients
- Budd-Chiari syndrome and extrahepatic portal obstruction associated with congenital antithrombin III deficiency
- Endoscopic Resection of Small Inflammatory Fibroid Polyp of the Colon
- Colonic Ulceration Caused by Administration of Loxoprofen Sodium
- Immunological and molecular analysis of B lymphocytes in low-grade MALT lymphoma of the stomach. Are there any useful markers for predicting outcome after Helicobacter pylori eradication?
- Reg protein : a possible mediator of gastrin-induced mucosal cell growth
- Helicobacter pylori-negative peptic ulcer in Japan : which contributes most to peptic ulcer development, Helicobacter pylori, NSAIDs or stress?
- Effect of Helicobacter pylori infection on Zollinger-Ellison syndrome
- Severe muscle damage induced by high carbohydrate intake from elemental diet in a patient with Crohn's disease
- Genetic analysis of a local recurrent tumor after colonic polypectomy
- A Huge Polypoid Type Early Gastric Neuroendocrine Cell Carcinoma
- Efficacy of surveillance and molecular markers for detection of ulcerative colitis-associated colorectal neoplasia
- Hormonal therapy
- Electrochemical Evaluation of Redox Enzyme Reaction Kinetics Based on Mediated Bioelectrocatalysis in Solution
- Essential role of Peyer's patches in the development of Helicobacter-induced gastritis
- Host factors are important in determining clinical outcomes of Helicobacter pylori infection
- Interaction of Helicobacter pylori-induced follicular gastritis and autoimmune gastritis in BALB/c mice with post-thymectomy autoimmune gastritis
- COMPARISON OF HISTOLOGICAL ANALYSIS AND ENDOSONOGRAPHIC FEATURES IN ESOPHAGEAL GRANULAR CELL TUMORS
- High Prevalence of Autoantibodies Against Carbonic Anhydrase II and Lactoferrin in Type 1 Diabetes : Concept of Autoimmune Exocrinopathy and Endocrinopathy of the Pancreas
- Biodegradable microspheres targeting mucosal immune-regulating cells : new approach for treatment of inflammatory bowel disease
- Case of Chronic Pancreatitis Involving an Autoimmune Mechanism That Extended to Retroperitoneal Fibrosis
- Intestinal drug delivery systems with biodegradable microspheres targeting mucosal immune-regulating cells for chronic inflammatory colitis
- Recent concept of autoimmune-related pancreatitis
- Role of a novel oncogenic protein, gankyrin, in hepatocyte proliferation
- Lens culinaris agglutinin-A-reactive alpha-fetoprotein as a marker for liver atrophy in fulminant hepatic failure
- Circulating antibody to hepatitis B core antigen does NOT always reflect the latent hepatitis B virus infection in the liver tissue
- INFLAMMATORY PROTRUDING LESION IN THE INTRAHEPATIC BILIARY DUCT DIAGNOSED ON NARROW BAND IMAGING-VIDEOCHOLANGIOSCOPY
- Endoscopic treatment of biliary complications after right-lobe living-donor liver transplantation with duct-to-duct biliary anastomosis
- Translational research on HGF : A phase I/II study of recombinant human HGF for the treatment of fulminant hepatic failure
- Molecular mechanisms of portal vein tolerance
- Scintigraphic study of regenerative nodules due to fulminant hepatic failure
- CD4 T cells monospecific to ovalbumin produced by Escherichia coli can induce colitis upon transfer to BALB/c and SCID mice
- The vast majority of gastric T cells are polarized to produce T helper 1 type cytokines upon antigenic stimulation despite the absence of Helicobacter pylori infection
- Massive rectal bleeding due to ileal tuberculosis
- Tumor thrombi in the portal vein system originating from gastrointestinal tract cancer
- Treatment of ruptured hepatocellular carcinoma
- De novo hepatitis B virus infection in hepatocellular carcinoma following eradication of hepatitis C virus by interferon therapy
- Reactivation of latently infected hepatitis B virus in a leukemia patient with antibodies to hepatitis B core antigen
- Monitoring of hepatocellular carcinoma, following proton radiotherapy, with contrast-enhanced color Doppler ultrasonography
- Multiple regression analysis for assesing the growth of small hepatocellular carcinoma: The MIB-1 labeling index is the most effective parameter
- Severe acute hepatitis A associated with acute pure red cell aplasia
- Multivariate analysis of risk factors for hepatocellular carcinoma in patients with hepatitis C virus-related liver cirrhosis
- New, Effective Treatment Using Proton Irradiation for Unresectable Hepatocellular Carcinoma
- 1A-03 Cross-correlation studies of muscle synergism in the triceps surae muscles during sustained contraction(Muscular Function, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and Sports Physiology July 30-31, (Tokyo))
- Effect of oxygen radical on apoptosis in human submandibular gland cell lines
- The effect of tacrolimus (FK-506) on Japanese patients with refractory Crohn's disease
- Comparison of Bone Mineral Density and Area of Newly Formed Bone Around Ti-15%Zr-4%Nb-4%Ta Alloy and Ti-6%Al-4%V Alloy Implants
- Narrow-band imaging of the gastrointestinal tract
- Diabetes Mellitus and Cardiomyopathy : Association With Mutation in the Mitochondrial tRNA^gene
- The Rat Intrinsic Factor Gene: Its 5'-Upstream Region and Chief Cell-Specific Transcription
- Case of mediastinal seminoma with testicular microlithiasis
- Efficacy of primary hormonal therapy for patients with localized and locally advanced prostate cancer : A retrospective multicenter study
- CARDIAC FUNCTION IN PATIENTS WITH CHRONIC RENAL FAILURE SHOWING HYPOTENSION DURING HOMO * DIALYSIS : ASSESSMENNT WITH CARDIAC BLOOD POOL SCINTIGRAPHY BEFORE AND AFTER HEMODIALYSIS
- ASSESSMENT OF CARDIAC FUNCTION BEFORE AND IMMEDIATELY AFTER HEMODIALYSIS USING 99m-Tc BLOOD POOL SCINRIGRAPHY
- CLINICAL FEATURES OF CORONARY HEART DISEASE IN CHRONIC HOMEDIALYSIS PATIENTS
- 2AD4 Effects of warming-up on metabolic and circulatory responses during high-intensity exercise(The Proceeding of the 14th Annual Meeting of Japan Society of Exercise and Sports Physiology July 29-30, (Hiroshima))
- 2B-11 Effects of a sprint-training under a hypobaric hypoxic condition on high-intensity exercise performance(Sports Physiology and Others, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and Sports Physiology July 30-31, (Tokyo))
- P2-2 Capillary supply and gene expression of angiogenesis-related factors in murine skeletal muscle following denervation(The Proceedings of the 12th Annual Meetings of Japan Society of Exercise and Sports Physiology)
- 2P01 Changes in μ-calpain and m-calpain expression in atrophied muscle
- 2C01 Metabolic profile of high intensity intermittent exercises
- 3P16:Histopathological studies of the stability of fine wire electrodesin rat skeletal muscle in situ
- Refractory enterovesical and duodenocolic fistulas in Crohn's disease successfully managed with tacrolimus
- EOSINOPHILIC GASTROENTERITIS WITH PREDOMINANT MUSCULAR LAYER DISEASE : FEATURE OF ENDOSCOPIC ULTRASONOGRAPHY
- Reg protein is a unique growth factor of gastric mucosal cells
- Gastrointestinal follicular lymphoma: review of the literature.
- What is responsible for the development of the distinctive pattern of gastritis induced by Helicobacter pylori infection?
- Systematic review : cytomegalovirus infection in inflammatory bowel disease
- Perivascular Epithelioid Cell Tumor (PEComa) of the Liver Diagnosed by Contrast-enhanced Ultrasonography
- New approach for analysis of muscle oxygen consumption: Deoxygenation rate/ motor unit activity ratio (第55回日本体力医学会大会) -- (International session)
- Perfusion CT is superior to angiography in predicting pancreatic necrosis in patients with severe acute pancreatitis.
- Unresponsiveness of GH and Cortisol to Insulin-Hypoglycemia in a Patient with Sub-total Pancreatectomy
- Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy : results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial
- Acute Airway Obstruction in a Patient with Achalasia
- Involvement of activation-induced cytidine deaminase in the development of colitis-associated colorectal cancers.
- ON THE COMPONENTS OF TROPONIN
- Expression of vascular endothelial growth factor and its receptors in heart tissue following short-term swimming training
- Loss of RUNX3 expression by histone deacetylation is associated with biliary tract carcinogenesis
- Differences of image enhancement in image-enhanced endoscopy : narrow band imaging versus flexible spectral imaging color enhancement
- Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity : A multicenter, retrospective analysis in Japan
- Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011
- Investigation of pretreatment prediction of proton pump inhibitor (PPI)-resistant patients with gastroesophageal reflux disease and the dose escalation challenge of PPIs-TORNADO study : a multicenter prospective study by the Acid-Related Symptom Research
- Decrease in alpha-fetoprotein levels predicts reduced incidence of hepatocellular carcinoma in patients with hepatitis C virus infection receiving interferon therapy : a single center study
- Therapeutic effects of famotidine on chronic symptomatic gastritis : subgroup analysis from FUTURE study
- Regression of Hodgkin Lymphoma in Response to Antiviral Therapy for Hepatitis C Virus Infection
- Rescue Therapy with Tacrolimus for a Patient with Severe Ulcerative Colitis Refractory to Combination Leukocytapheresis and High-Dose Corticosteroid Therapy
- Gluten Sensitivity in Japanese Patients with Adultonset Cerebellar Ataxia
- Spontaneous Rupture of Liver Plasmacytoma Mimicking Hepatocellular Carcinoma
- Magnified Endoscopic View of Primary FollicularLymphoma at the Duodenal Papilla
- The Effect of Medical Treatment on Patients with Fistulizing Crohn's Disease: A Retrospective Study
- Bifid Tail of the Pancreas with Localized Acute Pancreatitis
- Small Bowel Anisakiasis with Self-limiting Clinical Course
- Successful telaprevir treatment in combination of cyclosporine against recurrence of hepatitis C in the Japanese liver transplant patients
- Acute Cerebral Infarction during Combination Chemotherapy with S-1 and Cisplatin for a Young Patient with a Mucin-Producing Adenocarcinoma of the Stomach
- Evaluating the Dynamic Behavior of Taper Joint Implants Under Different Loading Conditions:A Transient Dynamic Finite Element Analysis
- Characteristics of gastric B-cell lymphoma of mucosa-associated lymphoid tissue type involving multiple organs
- Conversion from Latent to Symptomatic Sheehan's Syndrome by Pegylated Interferon Therapy for Chronic Hepatitis C
- Diffuse gastroduodenitis and enteritis associated with ulcerative colitis and concomitant cytomegalovirus reactivation after total colectomy : report of a case
- Clinical characteristics of Japanese patients with eosinophilic esophagitis and eosinophilic gastroenteritis