Diabetes Mellitus and Cardiomyopathy : Association With Mutation in the Mitochondrial tRNA^<Leu(UUR)>gene
スポンサーリンク
概要
- 論文の詳細を見る
In this report, cardiac abnormalities in 2 diabetic patients with a mutation in the mitochondrial tRNA^<Leu(UUR)>gene are described. The 2 patients exhibited left ventricular dilation and diffuse decreased wall motion. Cardiac catheterization studies revealed normal coronary angiography. In both patients, light micro-scopic examination of hematoxylin and eosin-stained sections revealed myocyte hypertrophy and perinuclear vacuolization and electron microscopy revealed an increase in the number and size of mitochondria and abnormal configuration of cristae. These findings suggest that mutations in mitochondrial DNA, such as an A→G mutation at position 3243, should be considered as a cause not only of diabetes mellitus but also of cardiac involvement in patients with diabetes mellitus.
- 社団法人日本循環器学会の論文
- 1998-03-20
著者
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井上 聡子
神戸大学医学部第一内科
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Inoue Satoko
First Department Of Internal Medicine
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Yokoyama Mitsuhiro
Department Of Cardiology Kobe University Graduate School Of Medicine
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Yokoyama Mitsuhiro
First Department Of Internal Medicine Kobe University School Of Medicine
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Yokota Yoshiyuki
Division Of Cardiovascular And Respiratory Medicine Kobe University Graduate School Of Medicine
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Yasaka Yoshinori
Division Of Cardiovascular And Respiratory Medicine Kobe University Graduate School Of Medicine
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Yasaka Yoshinori
Department Of Cardiology Himeji Cardiovascular Center
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Inoue Satoko
Department Of Gastroenterology & Hepatology Graduate School Of Medicine Kyoto University
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UENO HIROSHI
Department of Oral-Maxillofacial Surgery, Graduate School of Medicine, The University of Tokyo
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Yokota Yoshiyuki
Faculty of Health Science, Kobe University School of Medicine
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Shiotani Hideyuki
Faculty of Health Science, Kobe University School of Medicine
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Yoshida Yutaka
The First Department Of Internal Medicine Kobe University School Of Medicine
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Shiotani Hideyuki
Faculty Of Health Science Kobe University School Of Medicine
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Shiotani Hideyuki
Faculty Of Health Science Kobe University Of Medicine
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Yoshida Y
1gunma Univ.
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Ueno Hiroshi
Department Of Cardiology Himeji Cardiovascular Center
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Yokoyama Mitsuhiro
First Department Of Internal Medicine Kobe University
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Yoshida Yutaka
Hyogo Brain and Heart Center at Himeji
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Yokota Yoshiyuki
Faculity Of Health Science Kobe University School Of Medicine
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Yokoyama Mitsuhiro
First Department Of Internal Medicine
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Ueno Hiroshi
Department Of Anesthesiology Kyoto Prefectural University Of Medicine
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Ueno Hiroshi
Department Of Cardiovascular And Metabolism Hyogo Medical Center For Adults
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Yasaka Yosninori
The 1st Department Of Internal Medicine Kobe University School Of Medicine
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