Role of Angiotensin and the Clock System in the Circadian Regulation of Plasminogen Activator Inhibitor-1
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概要
- 論文の詳細を見る
The clock system and the renin-angiotensin system (RAS) have been reported toplay an important role in the circadian expression of plasminogen activator inhibitor-1(PAI-1) gene. However, the degree of involvement of these systems remains unknown.In the present study, we investigated the roles of the clock system and the RAS in thecircadian expression of PAI-1 in the peripheral tissues in vivo by using Cry1/Cry2double knockout (Cry1/2-deficient) and angiotensin type 1 (AT1a) receptor knockout(AT1a-deficient) mice. We observed no significant rhythmicity in the PAI-1 expressionin all tissues examined in Cry1/2-deficient mice; this suggests that the clock system isindispensable for the circadian expression of PAI-1. In AT1a-deficient mice, apparentcircadian oscillation of PAI-1 expression was observed in the lung and liver but not in the kidney, suggesting that AT1a-mediated signaling modulates the circadianexpression of PAI-1 in a tissue-specific manner.
- 神戸大学の論文
著者
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YOKOYAMA Mitsuhiro
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe Universit
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Yokoyama Mitsuhiro
Department Of Cardiovascular Medicine Awaji Prefectural Hospital
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Yokoyama Mitsuhiro
Department Of Internal Medicine Division Of Cardiovascular Medicine Kobe University Graduate School
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Yokoyama Mitsuhiro
Department Of Cardiology Kobe University Graduate School Of Medicine
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HIRATA Ken-ichi
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate Schoo
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Yokoyama Mitsuhiro
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Yokoyama M
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Tsujino Takeshi
Department Of Radiation Biology And Medical Genetics Osaka University Graduate School Of Medicine
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Yokoyama M
Department Of Cardiovascular Medicine Awaji Prefectural Hospital
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OKAMURA HITOSHI
Department of Anatomy, Kyoto Prefectural University of Medicine
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Yokoyama Mitsuhiro
Kobe University Graduate School Of Medicine
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Yokoyama Mitsuhiro
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Midicine Kobe University
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Nonaka Hidemi
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate Schoo
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Nonaka Hidemi
Division Of Cardiovascular Medicine Department Of Internal Medicine Kobe University Graduate School
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Okamura Hitoshi
Department Of Systems Biology Graduate School Of Pharmacological Science Kyoto University
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Okamura Hitoshi
Department Of Anatomy Kyoto Prefectural University Of Medicine
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Hirata Ken-ichi
Division Of Cardiovascular Medicine Department Of Internal Medicine Kobe University Graduate School
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Yokoyama Mitsuhiro
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Masuda Yoko
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate Schoo
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Emoto Noriaki
2Clinical Pharmacy, Kobe Pharmaceutical University
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Yagita Kazuhiro
Department of Cell Biology and Neuroscience, Osaka University Graduate School of Medicine
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Toda Takeshi
Department of Radiation Biology and Medical Genetics, Osaka University Graduate School of Medicine
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Masuda Yoko
Division Of Cardiovascular Medicine Department Of Internal Medicine Kobe University Graduate School
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Toda Takeshi
Department Of Biology Faculty Of Science And High Technology Research Center Konan University
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Yokoyama Mitsuhiro
First Department Of Internal Medicine Kobe University
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Yokoyama Mitsuhiro
Dept. Of Intern. Med. Div. I Kobe Univ. School Of Med.
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Todo Takeshi
Department Of Medical Genetics Graduate School Of Medicine Osaka University
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Yokoyama Mitsuhiro
The First Department Of In Internal Medicine Kobe University School Of Medicine
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Hirata Kenichi
Division Cardiovascular And Respiratory Medicine Kobe University Graduate School Of Medicine
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Yokoyama Mitsuhirc
The First Department Of Internal Medicine Kobe University School Of Medicine
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Yokoyama Mitsuhiro
Division Of Cardiovascular Medicine Kobe University Graduate School Of Medicine
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Yokoyama Mitsuhiro
The 1st Department Of Internal Medicine Kobe University School Of Medicine
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Hirata Ken-ichi
Division Of Cardiovascular Medicine Department Of Internal Medicine Kobe University Graduate School
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Yokoyama Mitsuhiro
The Department Of Internal Medicine (1st Division) Kobe University School Of Medicine
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Yokoyama Mitsuhiro
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Yagita Kazuhiro
Department Of Cell Biology And Neuroscience Osaka University Graduate School Of Medicine
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Yagita Kazuhiro
Department Of Anatomy And Brain Science Kobe University School Of Medicine
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Okamura Hitoshi
Department Of Anatomy Kobe University School Of Medicine
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Okamura Hitoshi
Department Of Anatomy And Brain Science Kobe University School Of Medicine
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Toda Takeshi
Department Of Applied Chemistry School Of Engineering Nagoya University
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Yokoyama Mitsuhiro
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University Graduate School Of Medical Science
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HIRATA Ken-ichi
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
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