Correlation of Connexin43 Expression and Late Ventricular Potentials in Nonisehemic Dilated Cardiomyopathy
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概要
- 論文の詳細を見る
Nonischemic dilated cardiomyopathy (DCM) is associated with a high risk of sudden cardiac death. Signal-aver-aged electrocardiography (SAECG) is a useful clinical tool for detecting late ventricular potentials (LP). Gap junction alterations have recently been shown to be involved in the pathogenesis of ventricular arrhythmias in DCM; however, the possible relationship between gap junctional connexin43 (Cx43) expression and SAECG has not yet been evaluated. In the present study 16 patients (47±13 years) with DCM who had undergone SAECG testing were evaluated. In each patient, the expression of Cx43 proteins was qualitatively and quantitatively determined using immunoconfocal microscopy and right ventricular biopsy specimens. The level of expression of Cx43 protein was defined as the proportion of tissue area occupied by Cx43 (percent tissue area) in each test area. The abundance and distribution of the Cx43 signal was assessed in relation to LP. Late ventricular potentials were positive in 5 patients (LP (+) group) and negative in 11 patients (LP (-) group). The incidence of sustained ventricular tachycardia in the LP (+) group was higher than that in the LP (-) group (80% vs 18%, p=0.04). The percent tissue area of Cx43 in the LP (+) group was significantly lower than that in the LP (-) group (p=0.02). Furthermore, Cx43 protein in the LP (+) group was distributed more heterogeneously than that in the LP (-) group (p=0.00l). The heterogeneous expression of Cx43 protein may contribute to impaired ventricular conduction, which may be related to the LP detected on SAECG. (Circ J 2003; 67: 1017-1021)
- 社団法人日本循環器学会の論文
- 2003-11-20
著者
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YOKOYAMA Mitsuhiro
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe Universit
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ISHIDA Akihiko
Division of Biotechnology and Molecular Chemistry, Graduate School of Engineering, Hokkaido Universi
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Yokoyama Mitsuhiro
Department Of Internal Medicine Division Of Cardiovascular Medicine Kobe University Graduate School
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Yokoyama Mitsuhiro
富山大学 医学部バイオ統計学臨床疫学
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Yokoyama Mitsuhiro
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Yokoyama Mitsuhiro
神戸大学 循環器内科学
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Ohnishi Yoshio
First Department of Internal Medicine Kobe University School of Medicine
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Yoshida Akihiro
Division of Cardiovascular Medicine, Himeji Cardiovascular Center
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Ohnishi Yoshio
The First Department Of Internal Medicine Kobe University School Of Medicine
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Ohnishi Yoshio
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Okajima Katsunori
Division of Cardiology, Hjimeji Cardiovascular Center
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Kitamura Hidetsuna
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe Universit
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Galeano Erdulfo
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe Universit
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Kubo Shinya
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe Universit
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Fukuzawa Kouji
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe Universit
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Takano Takatsugu
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe Universit
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Kubo Shinya
Department Of Internal Medicine Division Of Cardiovascular Medicine Kobe University Graduate School
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Fukuzawa Kouji
Division Of Cardiovascular Medicine Department Of Internal Medicine Kobe University Graduate School
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Ishida Akihiko
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Ishida Akihiko
Division Of Biotechnology And Molecular Chemistry Graduate School Of Engineering Hokkaido University
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Yoshida Akihiro
Kobe University Graduate School of Medicine
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Okajima Katsunori
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Fukuzawa Koji
Division Of Cardiovascular Medicine Department Of Internal Medicine Kobe University Graduate School
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Kitamura Hidetsuna
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Miyasaka Yoko
Cardiovascular Division Department Of Medicine Ii Kansai Medical University
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Yoshida Akihiro
Division Of Cardiology Department Of Internal Medicine St. Marianna University School Of Medicine
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Takano Takatsugu
Department Of Internal Medicine Division Of Cardiovascular Medicine Kobe University Graduate School
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Erdulfo J.
Department Of Cardiovascular And Respiratory Medicine Kobe University Graduate School Of Medicine
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Fukuzawa Kouji
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Ohnishi Yoshio
Division Of Cardiovascular And Respiratory Medicine Department Of Internal Medicine Kobe University
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Galeano Erdulfo
Department Of Cardiovascular And Respiratory Medicine Kobe University Graduate School Of Medicine
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Yokoyama Mitsuhiro
Department Of Internal Medicine Division Of Cardiovascular Medicine Kobe University Graduate School
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Yoshida Akihiko
Department Of Internal Medicine Division Of Cardiovascular Medicine Kobe University Graduate School
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