Hypnotic and Sleep Quality-Enhancing Properties of Kavain in Sleep-Disturbed Rats
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概要
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The present study was performed to investigate the effects of kavain on the sleep-wake cycle in comparison with that of rilmazafone and diphenhydramine using sleep-disturbed rats. Electrodes for the electroencephalogram (EEG) and electromyogram (EMG) were implanted into Wistar rats. Total awake time, non-rapid eye movement (non-REM) sleep and rapid eye movement (REM) sleep were measured for 6 h. Kavain and rilmazafone showed a significant shortening in sleep latency, decreased awake time, and increased non-REM sleep time. On the other hand, significant shortening of the sleep latency was observed following the administration of diphenhydramine, while no effects were observed on the awake and non-REM sleep time. Moreover, kavain showed a significant increase in delta activity during non-REM sleep in sleep-disturbed rats, whereas a significant decrease in delta power during non-REM sleep was observed with rilmazafone. These results clearly indicate that kavain is a compound with not only hypnotic effects, but also sleep quality–enhancement effects.
- 2009-11-20
著者
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Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Takeda Yasuhiro
Department of Life and Materials Engineering, Nagoya Institute of Technology
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SHINOMIYA Kazuaki
Department of Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okay
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KITAMURA Yoshihisa
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Kamei Chiaki
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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TSUTSUI Ryuki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Obara Yoshihito
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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Takeda Yasuhiro
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Takeda Yasuhiro
Department Of Animal Science Utsunomiya University
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Kanai Yoshihito
Department Of Pharmaceutical Care And Health Sciences Okayama University Graduate School Of Medicine
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Kitamura Yoshihisa
Department Of Neurobiology Kyoto Pharmaceutical University
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Kitamura Yoshihisa
Department Of Neuropharmacology Faculty Of Pharmaceutical Sciences Fukuoka University
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Kitamura Y
Department Of Neurobiology Kyoto Pharmaceutical University
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Kitamura Y
Shimizu Pharmaceutical Co. Ltd. Shizuoka Jpn
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Shinomiya Kazuaki
Department Of Pharmaceutical Care And Health Sciences Okayama University Graduate School Of Medicine
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Shinomiya Kazuaki
Department Of Anatomy And Physiology Faculty Of Pharmaceutical Sciences Kinki University
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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Kamei Chiaki
Dep. Of Medicinal Pharmacology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Kamei Chiaki
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Tsutsui Ryuki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
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KITAMURA Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
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