Experimental Allergic Conjunctivitis in Guinea Pigs Induced by Japanese Cedar Pollen
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概要
- 論文の詳細を見る
We report a new experimental allergic conjunctivities with Japanese cedar pollen as antigen in guinea pigs, and the immunological characteristics of this model were also elucidated. Allergic conjunctivitis was developed by immunization in guinea pigs with a mixture containing Japanese cedar pollen and killed Bordetella pertussis. When local application of Japanese ceder pollen suspension 14 d after systemic immunization was performed every 3 d, remarkable conjunctivitis was observed from 20 to 35 d. Increase in vascular permeability and decrease in histamine contents of the conjunctiva were also observed after local application of antigen. Passive cutaneous anaphylactic (PCA) reactions revealed that both IgG- and IgE-rich antibodies were produced in this model. Chlorpheniramine, ketotifen and levocabastine were effective in inhibiting cedar pollen-induced conjunctivities. Although a high concentration was needed, tranilast and amlexanox also showed significant inhibition of conjunctivitis induced by cedar pollen.
- 公益社団法人日本薬学会の論文
- 2000-05-01
著者
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Kamei Chiaki
Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and
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SUGIMOTO Yukio
Departmment of Pharmacology, Faculty of Pharmaceutical Siences, Okayama University
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Sugimoto Yukio
Department Of Medicinal Pharmacology Okayama University Graduate School Of Medicine Dentistry And Ph
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Kamei Chiaki
Department Of Medical Pharmacology Okayama University Graduate School Of Medicine Dentistry And Phar
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TAKADA Miho
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
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YAMADA Tamao
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
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NAKAHARA Hiroto
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
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IZUSHI Keiji
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University
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Takada Miho
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Izushi Keiji
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Yamada Tamao
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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Nakahara Hiroto
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Okayama University
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